Resources Repository
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GuidelinesPublication 2011HPV Vaccine Introduction in LMIC's: Guidance on the Use of Cost-Effectiveness Models
This article is a literature review of HPV vaccination models suitable for low-income and middle-income …
This article is a literature review of HPV vaccination models suitable for low-income and middle-income country use to provide information about the feasibility of using such models in a developing country setting. The authors evaluated models in terms of their capacity, requirements, limitations and comparability. Their literature review identified six HPV vaccination models suitable for low-income and middle-income country use and representative of the literature in terms of provenance and model structure. Each model was…
Mathematical Models | Calibration/Validation | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Health Systems | Clinical Care | Health/Medicine | Science/Technology | Global -
BriefPublication 2023Dynamic Mortality Modeling: Incorporating Predictions of Future General Population Mortality into CEA
This study addresses the limitations of conventional static approaches in health economic modeling by proposing …
This study addresses the limitations of conventional static approaches in health economic modeling by proposing a dynamic general population mortality modeling method. Using a replication of the axicabtagene ciloleucel model from NICE appraisal TA559, the authors demonstrate the potential impact of this approach on estimating life-years and cost-effectiveness. The model utilizes national mortality projections and updates mortality rates annually, considering different assumptions around age distribution. Results show that incorporating dynamic calculations increases undiscounted life-years attributed…
Mathematical Models | Cost-Effectiveness Analysis | Health/Medicine | Europe -
BriefPublication 2023Simulation Modeling to Guide Priority Setting in Global Maternal Health
This study developed the Global Maternal Health (GMatH) microsimulation model to evaluate maternal health policy …
This study developed the Global Maternal Health (GMatH) microsimulation model to evaluate maternal health policy interventions across 200 countries and territories from 1990 to 2050. It addresses challenges in measuring maternal mortality by simulating individual women's reproductive lifecycles. Various interventions, including family planning and facility-based care, were simulated to compare against a baseline scenario projecting the global maternal mortality ratio (MMR) to decrease to 167 per 100,000 live births by 2030. Results suggest that while…
Microsimulation | Cost-Effectiveness Analysis | Maternal/Reproductive Health | Policy/Regulation | Health/Medicine | Global -
EditorialPublication 2020Waiting for Certainty on COVID-19 Antibody Tests — At What Cost?
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation …
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation policy to reduce COVID-19 transmission. For example: Could we screen for serologic antibodies as a proxy for possible immunity and identify people who could return to the workplace with less severe mitigation measures? The authors acknowledge the uncertainties raised by many policy actors, including the WHO, such as, "Do antibodies confer immunity and, if so, for how long? How accurate is…
Probability/Bayes | Test Performance | Technology Assessment | Infectious Diseases | Health Systems | Policy/Regulation | Government/Law | Health/Medicine | Global | North America -
EditorialPublication 2018Combining A4R and MCDA in Priority Setting for Health
Multiple criteria decision analysis (MCDA) has been proposed as a method for determining the criteria …
Multiple criteria decision analysis (MCDA) has been proposed as a method for determining the criteria to be used in health technology assessment. A standard criticism of MCDA is that it lacks attention to securing legitimacy for its decisions. Accountability for reasonableness (A4R) proposes four conditions (publicity, relevance, revisability and enforcement) that must be met if legitimacy and fairness are to be ascribed to decisions about priority setting.The relevance condition of A4R has been criticized for…
Priority Setting/Ethics | Preferences/Values | Health/Medicine -
GuidelinesPublication 2016Decision Models in Clinical Preventive Services Recommendations
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on …
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on comprehensive systematic reviews of the best available evidence. Decision models provide a complementary, quantitative approach to support the USPSTF as it deliberates about the evidence and develops recommendations for clinical and policy use. This article describes the rationale for using modeling, an approach to selecting topics for modeling, and how modeling may inform recommendations about clinical preventive services.
Mathematical Models | Health Outcomes | Evidence Synthesis | Decision Analysis | Health Systems | Policy/Regulation | Health/Medicine | North America -
GuidelinesPublication 2016Methods for Health Economic Evaluation of Vaccines
This article describes the development of a consensus for health economic evaluations of vaccines to …
This article describes the development of a consensus for health economic evaluations of vaccines to support the development of national guidelines in Europe. While guidelines advocating more standardization of health economic evaluations exist, this article aims to address several immunization-specific aspects (e.g. indirect effects or discounting approach) which are still a subject of debate. The systematic literature review search was informed by expert opinion. 2,838 articles were returned from the search and 26 were finally…
Dynamic Transmission | Costing Methods | Cost-Effectiveness Analysis | Infectious Diseases | Health Systems | Health/Medicine | Europe -
GuidelinesPublication 2015USPSTF Procedure Manual
The U.S. Preventive Services Task Force (USPSTF) Procedure Manual describes the methods used by the …
The U.S. Preventive Services Task Force (USPSTF) Procedure Manual describes the methods used by the Task Force to ensure that its recommendations are scientifically sound, reproducible, and well documented. The Manual provides a high-level description of the Task Force’s structure, governance, and processes for selecting topics, reviewing evidence, soliciting and responding to public input, and arriving at a recommendation. It is intended as a guide for anyone who is interested in the Task Force, Task…
Priority Setting/Ethics | Evidence Synthesis | Technology Assessment | Health Systems | Policy/Regulation | Government/Law | Health/Medicine | North America -
GuidelinesPublication 2013Decision and Simulation Modeling in Systematic Reviews
The purpose of this review is to provide guidance for determining when incorporating a decision-analytic …
The purpose of this review is to provide guidance for determining when incorporating a decision-analytic model alongside a systemic review would be of added value for decision making purposes. The purpose of systematic reviews is to synthesize the current scientific literature on a particular topic in the form of evidence reports and technology assessments to assist public and private organizations in developing strategies that improve the quality of health care and decision making. However, there…
Mathematical Models | Evidence Synthesis | Decision Analysis | Infectious Diseases | Child/Nutrition | Chronic Disease/Risk | Health/Medicine | North America