Resources Repository
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ArticlePublication 2020Post-Heart Transplantation Diabetes Mellitus
This retrospective study analyzed glycemic trends, incidence of post-transplant diabetes mellitus (PTDM), and associated risk …
This retrospective study analyzed glycemic trends, incidence of post-transplant diabetes mellitus (PTDM), and associated risk factors in a cohort of patients who underwent first-time heart transplantation. Univariate analyses compared patients with and without pretransplant diabetes mellitus. Multivariate regression analyses determined the association between PTDM and different risk factors. Finally, trends in glucometrics and other outcomes are described across follow-up time points.
Health/Medicine | Chronic Disease/Risk | North America -
ArticlePublication 2020Post-Transplantation Diabetes Incidence and Risk Factors
Most prior studies characterizing post-transplantation diabetes mellitus have been limited to single-cohort, single-organ studies. This …
Most prior studies characterizing post-transplantation diabetes mellitus have been limited to single-cohort, single-organ studies. This retrospective study determined post-transplantation diabetes mellitus across organs by comparing incidence and risk factors among 346 liver and 407 kidney transplant recipients from a single center. The authors used univariate and multivariate regression-based analyses to determine the association of various risk factors and post-transplantation diabetes mellitus in the two cohorts, as well as differences in glucometrics and insulin use across…
Health/Medicine | Chronic Disease/Risk | North America -
EditorialPublication 2019Quality Transparency in Health Care
The immediate promise of using public reporting to increase quality transparency is that it will …
The immediate promise of using public reporting to increase quality transparency is that it will enable consumers to choose the providers best suited to their needs and thereby lead to improved patient outcomes and welfare. Unfortunately, however, early empirical findings failed to detect such anticipated benefits from public reporting. For example, studies have indicated that the launch of the Hospital Compare website and other efforts aimed at increasing quality transparency have not resulted in improved…
Health/Medicine | Policy/Regulation | North America -
ArticlePublication 2022Vaccinations versus Lockdowns to Prevent COVID-19 Mortality
This analysis estimated the costs associated with preventing Covid-19 deaths by vaccinations versus lockdowns. Publicly …
This analysis estimated the costs associated with preventing Covid-19 deaths by vaccinations versus lockdowns. Publicly available datasets from the Israeli Ministry of Health were used to model the parameters of the pandemic in Israel. The Oxford COVID-19 Government Response Tracker was used for quantitative data on government policies. Data on the Israeli economy were taken from the Central Bureau of Statistics. The models demonstrate that the first lockdown prevented 1022 COVID-19 deaths at the cost…
Health/Medicine | Decision Theory | Costing Methods | Health Outcomes | State-Transition | Decision Analysis | Infectious Diseases | Policy/Regulation | Economics/Finance | Government/Law | Middle East & North Africa -
ArticlePublication 2022COVID-19 Response: The Need for Economic Evaluation
COVID-19-related policies are fraught with trade-offs. Many of these trade-offs involve dimensions that can be …
COVID-19-related policies are fraught with trade-offs. Many of these trade-offs involve dimensions that can be quantitatively weighed using economic evaluation, such as those between health and cost outcomes. Other types of dimensions, such as those involving equity or autonomy, can be harder to quantify but should be considered in a comprehensive health policy decision-making context nonetheless. The authors of this New England Journal of Medicine Perspectives article outline how methods of economic evaluation and decision…
Health/Medicine | Priority Setting/Ethics | Benefit-Cost Analysis | Cost-Effectiveness Analysis | Infectious Diseases | Policy/Regulation | Economics/Finance | Global | North America -
ArticlePublication 2022Spatial-Mechanistic Model to Estimate Sub-National Tuberculosis Burden in Brazilian Municipalities
Reliable subnational estimates of TB incidence are needed to focus disease control resources in areas …
Reliable subnational estimates of TB incidence are needed to focus disease control resources in areas of highest need. This study developed an approach for generating small area estimates of TB incidence, and the fraction of individuals missed by routine case detection, based on available notification and mortality data. The approach is demonstrated by estimating TB outcomes for 5568 municipalities in Brazil, revealing substantial subnational differences in disease burden and other metrics useful for designing high-impact…
Health/Medicine | Health Outcomes | Mathematical Models | Infectious Diseases | Latin America & Caribbean -
ArticlePublication 2022Re-Evaluating the Health Impact and Cost-Effectiveness of Tuberculosis Prevention for Modern ART Cohorts
TB preventive therapy (TPT) is widely accepted to be cost-effective for reducing TB incidence in …
TB preventive therapy (TPT) is widely accepted to be cost-effective for reducing TB incidence in HIV-infected individuals receiving antiretroviral therapy (ART). However, as individuals initiate ART earlier in the course of disease, TB incidence is lower, and it is unclear how ART cost-effectiveness has changed. This study assessed the cost-effectiveness of TPT in contemporary ART cohorts. The authors developed a microsimulation model of TB and HIV and parameterised it using data from a large HIV…
Health/Medicine | Microsimulation | Cost-Effectiveness Analysis | Infectious Diseases | Global | Sub-Saharan Africa -
ArticlePublication 2022Cost-Effectiveness of Masked Hypertension Screening and Treatment
The study assessed the health and economic outcomes of screening and treating masked hypertension in …
The study assessed the health and economic outcomes of screening and treating masked hypertension in U.S. adults using the Cardiovascular Disease (CVD) Policy Model, a microsimulation model. The model simulated 100,000 adults suspected of having masked hypertension (office blood pressure [BP] of 120–129/<80 mm Hg, not on antihypertensive medications, and without a history of CVD). Interventions included: usual care alone, usual care with ambulatory BP monitoring (ABPM), and usual care with home BP monitoring (HBPM).…
Health/Medicine | Microsimulation | Cost-Effectiveness Analysis | Chronic Disease/Risk | Clinical Care | North America -
ReviewPublication 2022Systematic Review of Economic Evaluations of COVID-19 Interventions: Non-Health Impacts and Distributional Issues
The authors conducted a systematic review of economic evaluations of COVID-19 interventions and assessed whether …
The authors conducted a systematic review of economic evaluations of COVID-19 interventions and assessed whether they incorporated non-health impacts and distributional concerns. Among the 70 articles included, more than half (56%) included at least one non-health impact, although only 21% incorporated non-economic consequences. Only 17% examined subgroups of interest. The median ICER for the entire sample was $67,000/quality-adjusted life-year (QALY) (interquartile range [IQR] $9000-$893,000/QALY). Interventions including a pharmaceutical component yielded a median ICER of $93,000/QALY (IQR…
Health/Medicine | Evidence Synthesis | Cost-Effectiveness Analysis | Infectious Diseases | Social Determinants | Culture/Society | Economics/Finance | North America