Post-Transplantation Diabetes Incidence and Risk Factors
2020
Most prior studies characterizing post-transplantation diabetes mellitus have been limited to single-cohort, single-organ studies. This retrospective study determined post-transplantation diabetes mellitus across organs by comparing incidence and risk factors among 346 liver and 407 kidney transplant recipients from a single center.
The authors used univariate and multivariate regression-based analyses to determine the association of various risk factors and post-transplantation diabetes mellitus in the two cohorts, as well as differences in glucometrics and insulin use across time points. They found a higher incidence among liver versus kidney transplant recipients at 1-year post-transplant, concluding that kidney and liver transplant patients have different post-transplantation diabetes mellitus risk profiles, both in terms of absolute risk as well as time course of risk. Management of this population should better reflect risk heterogeneity to short-term need for insulin therapy and potentially long-term outcomes.
Post-Transplantation Diabetes Incidence and Risk Factors
Source:
Munshi VN, Saghafian S, Cook CB, Werner KT, Chakkera HA. Comparison of Post-Transplantation Diabetes Mellitus Incidence and Risk Factors between Kidney and Liver Transplantation Patients. PLOS ONE 2020; 15 (1). https://doi.org/10.1371/journal.pone.0226873