Resources Repository
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ReviewPublication 2017Model-Based Economic Evaluation of Treatments for Depression: A Systematic Review
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies …
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies evaluating the cost-effectiveness of treatments for depression and examine the appropriateness of different modelling technique for simulating the natural course of depression. The review yielded 41 model-based studies, of which 21 used decision trees (DTs), 15 used cohort-based state-transition Markov models (CMMs), two used individual-based state-transition models (ISMs), and three used discrete-event simulation (DES) models. Just over half of the…
Microsimulation | Mathematical Models | State-Transition | Health/Medicine | Cost-Effectiveness Analysis | Mental Health -
ReviewPublication 2017Use of Mathematical Models of Chlamydia Transmission to Address Public Health Policy Questions
This review provides an overview of chlamydia transmission models and offers perspective on how mathematical …
This review provides an overview of chlamydia transmission models and offers perspective on how mathematical modeling has responded over time to additional empirical evidence in order to address policy questions related to prevention of chlamydia infection. The authors reviewed published chlamydia models to understand the range of approaches used for policy analyses and how the studies have responded to developments in the field. The authors identified 47 publications reporting on 29 mathematical models through a…
Mathematical Models | Dynamic Transmission | State-Transition | Health/Medicine | Infectious Diseases | Clinical Care | North America -
ReviewPublication 2014Markov Modeling & Discrete Event Simulation in Health Care: Systematic Comparison
This review assesses whether the use of Markov modeling (MM) or discrete event simulation (DES) …
This review assesses whether the use of Markov modeling (MM) or discrete event simulation (DES) for cost-effectiveness analysis (CEA) may alter healthcare resource allocation decisions. A systematic literature search and review of empirical and non-empirical studies comparing MM and DES techniques used in the CEA of healthcare technologies was conducted. The primary advantages described for DES over MM were the ability to model queuing for limited resources, capture individual patient histories, accommodate complexity and uncertainty,…
Microsimulation | Mathematical Models | State-Transition | Health/Medicine | Health Systems | Clinical Care -
GuidelinesPublication 2012Model Transparency and Validation: A Report of the ISPOR-SMDM Modeling Task Force-7
This paper discusses how to improve trust in the use of health care models through …
This paper discusses how to improve trust in the use of health care models through validation and transparency. Validation involves face validity (wherein experts evaluate model structure, data sources, assumptions, and results), verification or internal validity (check accuracy of coding), cross validity (comparison of results with other models analyzing same problem), external validity (comparing model results to real-world results), and predictive validity (comparing model results with prospectively observed events). Recommendations are provided for nontechnical description…
Mathematical Models | Calibration/Validation | Costing Methods | Health/Medicine | Health Outcomes -
GuidelinesPublication 2012State-Transition Modeling: A Report of the ISPOR-SMDM Modeling Task Force-3
State-transition modeling includes both Markov model cohort simulation as well as individual-based (first-order Monte Carlo) …
State-transition modeling includes both Markov model cohort simulation as well as individual-based (first-order Monte Carlo) microsimulation. These models have been used in many different populations and diseases, and their applications range from personalized health care strategies to public health programs. Most frequently, state-transition models are used in the evaluation of risk factor interventions, screening, diagnostic procedures, treatment strategies, and disease management programs. Recommendations are made on choice of model type (cohort vs. individual-level model), model…
Microsimulation | Mathematical Models | State-Transition | Health/Medicine -
GuidelinesPublication 2012Dynamic Transmission Modeling: A Report of the ISPOR-SMDM Modeling Task Force-5
This paper reports the consensus-based guidelines on dynamic transmission modeling in health care. The transmissible …
This paper reports the consensus-based guidelines on dynamic transmission modeling in health care. The transmissible nature of communicable diseases is what sets them apart from other diseases modeled by health economists. The probability of a susceptible individual becoming infected at any one point in time (the force of infection) is related to the number of infectious individuals in the population, will change over time, and will feed back into the future force of infection. These…
Dynamic Simulation | Mathematical Models | Dynamic Transmission | Health/Medicine | Infectious Diseases -
ReviewPublication 2023Handbook of Vaccine Health Economics
The open-access book, "Handbook of Applied Health Economics in Vaccines," looks at the complexities of …
The open-access book, "Handbook of Applied Health Economics in Vaccines," looks at the complexities of vaccine discovery, financing, and distribution. It highlights the inadequacy of standard economic models for vaccines. The book explores alternative principles challenging market-based approaches and equips readers with tools for assessing costs and benefits through practical exercises. It serves as a comprehensive resource for decision-making in vaccine development and distribution and emphasizes the importance of considering broader perspectives beyond economic efficiency.…
Evidence Synthesis | Costing Methods | Health/Medicine | Health Outcomes | Decision Analysis | Benefit-Cost Analysis | Cost-Effectiveness Analysis | Policy/Regulation | Global | Graduate | Doctoral | Professional -
ReviewPublication 2018Primary & Secondary Prevention Interventions for Cardiovascular Disease in LMIC's
Motivated by the need for evidence on cardiovascular disease (CVD) interventions offering good value for …
Motivated by the need for evidence on cardiovascular disease (CVD) interventions offering good value for the money, the authors conducted a systematic review, including 50 studies. Included studies were those that reported full economic evaluations of individual and population-based interventions (pharmacologic and non-pharmacologic), for primary and secondary prevention of CVD among adults in LMIC. The majority of the studies were of modelled evaluations, with significant heterogeneity in methods. Most of the economic evaluations evaluated were…
Evidence Synthesis | Costing Methods | Health/Medicine | Health Outcomes | Chronic Disease/Risk | Global -
ReviewPublication 2017Validation and Calibration of Structural Models that Combine Information from Multiple Sources
This is a review of calibration and validation methods in mathematical modeling. Such models that …
This is a review of calibration and validation methods in mathematical modeling. Such models that attempt to capture structural relationships between their components and combine information from multiple sources are increasingly used in medicine. The authors provide an overview of methods for model validation and calibration and survey studies comparing alternative approaches. Model validation entails a confrontation of models with data, background knowledge, and other models, and can inform judgments about model credibility. Calibration involves…
Mathematical Models | Calibration/Validation | Health/Medicine