Resources Repository
-
ArticlePublication 2009Cost-Effectiveness of Alternative Pregnancy Termination Strategies in Mexico City
This study evaluated the health and economic outcomes associated with three alternative first-trimester abortion techniques …
This study evaluated the health and economic outcomes associated with three alternative first-trimester abortion techniques in Mexico City using a computer-based model to simulate induced abortion and its potential complications. Strategies included alternative modalities for first-trimester pregnancy termination: hospital-based dilatation and curettage (D&C), hospital-based manual vacuum aspiration (MVA), clinic-based MVA and medical abortion using vaginal misoprostol. Outcomes included number of complications, lifetime costs, life expectancy, and quality-adjusted life expectancy. Assuming all options were equally available,…
State-Transition | Health/Medicine | Maternal/Reproductive Health | Health Outcomes | Cost-Effectiveness Analysis | Latin America & Caribbean -
ArticlePublication 2008Mathematical Models of Cervical Cancer Prevention in the Asia Pacific Region
This article reports on a model-based approach to estimate averted cervical cancer cases and deaths, …
This article reports on a model-based approach to estimate averted cervical cancer cases and deaths, disability-adjusted life years (DALYs) and incremental cost-effectiveness ratios (I$/DALY averted) for vaccination of young adolescent girls against human papillomavirus (HPV) types 16 and 18. The authors used population-based and epidemiologic data for 25 countries in Asia (22 GAVI-Alliance eligible countries, Thailand, China and Japan). They found that an absolute reduction in lifetime cancer risk varied across countries, depending on incidence,…
Mathematical Models | Health/Medicine | Chronic Disease/Risk | Microsimulation | Calibration/Validation | Cost-Effectiveness Analysis | Infectious Diseases | Health Systems | Economics/Finance | Science/Technology | Asia & Pacific -
ArticlePublication 2008Mathematical Models of Cervical Cancer Prevention in Latin America and the Caribbean
This article reports on a model-based approach estimated averted cervical cancer cases and deaths, disability-adjusted …
This article reports on a model-based approach estimated averted cervical cancer cases and deaths, disability-adjusted life years (DALYs) and incremental cost-effectiveness ratios (I$/DALY averted) for human papillomavirus (HPV) vaccination of young adolescent girls using population and epidemiologic data for 33 countries in Latin America and the Caribbean (LAC). The authors found that an absolute reduction in lifetime cancer risk varied between countries, depending on incidence, proportion attributable to HPV-16 and 18, and population age-structure; for…
State-Transition | Health/Medicine | Chronic Disease/Risk | Costing Methods | Microsimulation | Calibration/Validation | Cost-Effectiveness Analysis | Infectious Diseases | Economics/Finance | Science/Technology | Latin America & Caribbean -
ArticlePublication 2008Development of an Empirically Calibrated Model of Gastric Cancer in Two High-Risk Countries
This paper presents an empirically calibrated mathematical model of gastric cancer and H. pylori in …
This paper presents an empirically calibrated mathematical model of gastric cancer and H. pylori in China and Colombia to provide qualitative insight into the cost-effectiveness of gastric cancer prevention strategies. Despite studies that have established the relationship between Helicobacter pylori and gastric cancer and H. pylori treatment reducing cancer incidence among individuals without preexisting precancerous lesions, screening for H. pylori is still being debated. The authors synthesized…!--?xml:namespace prefix = "o" ns = "urn:schemas-microsoft-com:office:office" /-->
Mathematical Models | Health/Medicine | Chronic Disease/Risk | Microsimulation | Calibration/Validation | Infectious Diseases | Latin America & Caribbean | Asia & Pacific -
ArticlePublication 2007Multiparameter Calibration of a Natural History Model of Cervical Cancer
This paper presents a two-step approach to model calibration of a comprehensive natural history model …
This paper presents a two-step approach to model calibration of a comprehensive natural history model of human papillomavirus (HPV) and cervical cancer. Using primary epidemiologic data from a longitudinal study of women in Brazil, a plausible range for each input parameter was identified that would produce model output within the 95% confidence intervals of the data. The authors then performed a simultaneous search over all input parameters to identify parameter sets that produced output consistent…
Mathematical Models | Health/Medicine | Chronic Disease/Risk | Microsimulation | Calibration/Validation | Infectious Diseases | Latin America & Caribbean -
BookPublication 1996Cost-Effectiveness in Health and Medicine, 1st Edition
In 1993, the US Public Health Service convened a panel of 13 nongovernment scientists and …
In 1993, the US Public Health Service convened a panel of 13 nongovernment scientists and scholars with expertise in economics, clinical medicine, ethics, and statistics to review the state of cost-effectiveness analysis and to develop recommendations for its conduct and use in health and medicine. Publishing their results in 1996, they proposed the most explicit set of guidelines (together with their rationale) ever defined on the conduct of CEAs. The panel recommended analysts include a "reference-case"…
Evidence Synthesis | Health/Medicine | Policy/Regulation | Preferences/Values | Priority Setting/Ethics | Costing Methods | Health Outcomes | Value of Information | Cost-Effectiveness Analysis | Health Systems | Economics/Finance | North America -
ReviewPublication 1982Decision Analysis: An Overview
This article, written for the non-decision analyst, describes what decision analysis is, what it can …
This article, written for the non-decision analyst, describes what decision analysis is, what it can and cannot do, why one should care to do this, and how one does it. Keeney describes decision analysis as "a formalization of common sense for decision problems which are too complex for informal use of common sense." He provides a more technical definition also, describing decision analysis as "a philosophy, articulated by a set of logical axioms, and a methodology…
Decision Analysis | Health/Medicine | Policy/Regulation | Decision Theory | Preferences/Values | Business/Industry | Economics/Finance | Energy/Engineering | Government/Law | Military/Defense | Science/Technology -
BookPublication 1978Swine Flu Affair: Decision-Making on a Slippery Disease
This report from the Institute of Medicine, The Swine Flu Affair: Decision-Making on a Slippery …
This report from the Institute of Medicine, The Swine Flu Affair: Decision-Making on a Slippery Disease, was written to review and critique the decisions made around the 1976 swine flu threat. In 1976, a small group of soldiers at Fort Dix were infected with a swine flu virus that was deemed similar to the virus responsible for the great 1918-19 world-wide flu pandemic. The U.S. government initiated an unprecedented effort to immunize every American against…
Decision Analysis | Health/Medicine | Policy/Regulation | Risk Analysis | Infectious Diseases | Health Systems | Science/Technology | North America