Cost-Effectiveness in Health and Medicine, 1st Edition


In 1993, the US Public Health Service convened a panel of 13 nongovernment scientists and scholars with expertise in economics, clinical medicine, ethics, and statistics to review the state of cost-effectiveness analysis and to develop recommendations for its conduct and use in health and medicine. Publishing their results in 1996, they proposed the most explicit set of guidelines (together with their rationale) ever defined on the conduct of CEAs. The panel recommended analysts include a "reference-case" analysis in all cost-effectiveness analyses designed to inform resource allocation.

Included in the book is a focused overview of the theoretical background underlying areas of controversy and of methodological alternatives. Separate chapters were included on important theoretical and practical issues encountered in measuring costs and effectiveness, evaluating outcomes, discounting, and dealing with uncertainty. Additional chapters on framing and reporting of CEAs elucidate the purpose of the analysis and the effective communication of its findings.

Chapters include:

  • Cost-Effectiveness Analysis as a Guide to Resource Allocation in Health: Roles and Limitations
  • Theoretical Foundations of Cost-Effectiveness Analysis
  • Framing and Designing the Cost-Effectiveness Analysis
  • Identifying and Valuing Outcomes
  • Assessing the Effectiveness of Health Interventions
  • Estimating Costs in Cost-Effectiveness Analysis
  • Time Preference
  • Reflecting Uncertainty in Cost-Effectiveness Analysis
  • Reporting Cost-Effectiveness Studies and Results


Related Files:


Gold MR, Siegel JE, Russell LB, Weinstein MC, eds. Cost-Effectiveness in Health and Medicine, 1st Edition. Oxford University Press 1996.