Resources Repository
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ReportPublication 2016Modeling to Inform Strategies to Improve Population Health
This workshop report summarizes a workshop convened by the Institute of Medicine to explore the potential …
This workshop report summarizes a workshop convened by the Institute of Medicine to explore the potential uses of simulation and other types of modeling for improving health. Participants worked to identify how modeling could inform population health decision making (selecting and refining potential strategies, ranging from interventions to investments) based on lessons learned from models that have been, or have not been, used successfully, opportunities and barriers to incorporating models into decision making, and data needs and…
Dynamic Simulation | State-Transition | North America | Policy/Regulation | Mathematical Models | Microsimulation | Decision Analysis | Chronic Disease/Risk | Environmental Health | Health Systems | Business/Industry | Climate/Environment | Government/Law | Health/Medicine -
ArticlePublication 2023Benefits and Costs of COVID-19 Vaccine Mandates
Written mid-pandemic, this article evaluates the direct costs and health benefits of requiring COVID-19 vaccinations …
Written mid-pandemic, this article evaluates the direct costs and health benefits of requiring COVID-19 vaccinations for U.S. federal employees and healthcare and private sector workers. These mandates were controversial and some were halted by litigation. If they had been implemented as intended, the net benefits would depend on the course of the pandemic. If a more transmissible variant (such as Omicron) emerges, the net benefits may be large. If the pandemic instead fades, the benefits…
State-Transition | North America | Policy/Regulation | Mathematical Models | Benefit-Cost Analysis | Infectious Diseases | Business/Industry | Economics/Finance | Government/Law | Health/Medicine -
ArticlePublication 2022Emerging Therapies for COVID-19: The Value of Information From More Clinical Trials
The COVID-19 pandemic necessitated time-sensitive policy and implementation decisions regarding new therapies in the face …
The COVID-19 pandemic necessitated time-sensitive policy and implementation decisions regarding new therapies in the face of uncertainty. This study aimed to quantify consequences of approving therapies or pursuing further research. The authors used a cohort state-transition model for hospitalized patients with COVID-19 to estimate quality-adjusted life-years (QALYs) and costs associated with multiple drug regimens and usual care. For each they assessed immediate approval, use only in research, emergency use authorization or reject. They conducted cost-effectiveness…
State-Transition | North America | Policy/Regulation | Value of Information | Benefit-Cost Analysis | Infectious Diseases | Economics/Finance | Europe -
ArticlePublication 2019Estimation of Eating Disorders Prevalence by Age and Associations with Mortality in a Simulated Nationally Representative U.S. Cohort
This analysis models the individual-level disease dynamics of eating disorders (ED) in the United States, …
This analysis models the individual-level disease dynamics of eating disorders (ED) in the United States, and estimates the association of increased treatment coverage with ED-related mortality. Using an individual-level Markov state transition model calibrated to nationally-representative US survey data from 2007 and 2011, the authors simulated a virtual cohort of 100,000 individuals (50% male) from birth to age 40 years and modelled 4 ED diagnoses: anorexia nervosa, bulimia nervosa, binge eating disorder, and other specified…
Calibration/Validation | North America | Mental Health | Health Outcomes | Microsimulation | Child/Nutrition -
EditorialPublication 2020Waiting for Certainty on COVID-19 Antibody Tests — At What Cost?
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation …
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation policy to reduce COVID-19 transmission. For example: Could we screen for serologic antibodies as a proxy for possible immunity and identify people who could return to the workplace with less severe mitigation measures? The authors acknowledge the uncertainties raised by many policy actors, including the WHO, such as, "Do antibodies confer immunity and, if so, for how long? How accurate is…
Probability/Bayes | North America | Policy/Regulation | Test Performance | Technology Assessment | Infectious Diseases | Health Systems | Government/Law | Health/Medicine | Global -
Resource PackWeb Portal, Teaching Resource 2018Resource Pack: Mental Health and Modeling
This resource pack, curated by the Center for Health Decision Science, features resources on modeling …
This resource pack, curated by the Center for Health Decision Science, features resources on modeling approaches applied to mental health. We aim to provide an overview of different techniques to guide researchers and practitioners in applying decision science and economic modeling to this public health challenge. More specifically, this resource pack contains review articles comparing different modeling techniques in the evaluation of treatments for depression, bipolar disorder and schizophrenia. The majority of articles in this…
State-Transition | North America | Mental Health | Costing Methods | Health Outcomes | Evidence Synthesis | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Chronic Disease/Risk | Health/Medicine | Europe -
Lesson/ModuleWeb Portal, Teaching Resource 2016Educational Module: Shale Gas Development
This module has been developed around the topic of the extraction of natural gas from …
This module has been developed around the topic of the extraction of natural gas from shale. This practice, commonly referred to as fracking, involves several practices that have complex and uncertain consequences. In the module, three scientific concepts are explored in order to elucidate how science is applied toward addressing real-world problems. The scientific concepts are: (1) correlation is not the same as causation, (2) hazard is not the same as risk, and (3) risk…
Probability/Bayes | North America | Policy/Regulation | Risk Analysis | Environmental Health | Business/Industry | Climate/Environment | Energy/Engineering | Government/Law | Science/Technology | Global | College | Graduate | Doctoral | Critical Thinking/Analysis | Decision Making/Leadership -
Lesson/ModuleWeb Portal, Teaching Resource 2016Educational Module: Forensic Pattern Recognition
This module uses latent print (fingerprint) identification as a case study of the broader category …
This module uses latent print (fingerprint) identification as a case study of the broader category of forensic pattern recognition evidence. The case of forensic pattern recognition evidence is meant, in turn, to be a case study of the broader issue of the interaction between science and law and policy. The case of fingerprinting identification poses challenging questions for legal professionals and policy-makers. Although fingerprint identification is one of the most widely used and widely trusted…
Probability/Bayes | North America | Policy/Regulation | Decision Theory | Decision Analysis | Government/Law | Science/Technology | Global | College | Graduate | Doctoral | Critical Thinking/Analysis | Decision Making/Leadership | Quantitative Literacy -
ArticlePublication 2015Population Health Model (POHEM): An Overview
This paper provides an overview of the rationale, methodology and applications of the Population Health …
This paper provides an overview of the rationale, methodology and applications of the Population Health Model (POHEM). POHEM is a health microsimulation model, developed at Statistics Canada in the early 1990s. The authors describe that POHEM draws together rich multivariate data from a wide range of sources to simulate the lifecycle of the Canadian population, specifically focusing on aspects of health. The model dynamically simulates individuals’ disease states, risk factors, and health determinants, in order…
Calibration/Validation | North America | Policy/Regulation | Costing Methods | Evidence Synthesis | Mathematical Models | Microsimulation | Chronic Disease/Risk | Health Systems | Clinical Care | Economics/Finance | Health/Medicine