Resources Repository
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Tutorial/PrimerPublication, Teaching Resource 2023Conducting Trial-Based Economic Evaluations Using R: A Tutorial
Trial-based economic evaluations are increasingly conducted to support healthcare decision-making but there are inevitable methodological …
Trial-based economic evaluations are increasingly conducted to support healthcare decision-making but there are inevitable methodological challenges. This tutorial provides step-by-step guidance on how to combine appropriate statistical methods using a ready-to-use R script, and addresses missing data, correlated costs and effects, baseline imbalances, and skewness of costs and/or effects. The authors also provide the theoretical background of these methods, and demonstrate their application through a simulated trial-based economic evaluation.
Evidence Synthesis | Costing Methods | Economics/Finance | Health/Medicine | Graduate | Doctoral | Professional | Quantitative Literacy -
Online LearningMultimedia, Teaching Resource 2024Cochrane Interactive Learning
Cochrane Interactive Learning provides over 10 hours of self-directed learning on the complete systematic review …
Cochrane Interactive Learning provides over 10 hours of self-directed learning on the complete systematic review process for both new and experienced authors of systematic reviews following Cochrane methodology. It is useful for both introductory-level learners and more experienced learners who want to refresh and update their knowledge. Trainers may use it for blended learning, combining the online modules as an introduction to more advanced learning in a face-to-face setting. Cochrane Interactive Learning consists of nine modules, each…
Evidence Synthesis | Test Performance | Technology Assessment | Health/Medicine | Global | College | Graduate | Doctoral | Professional | Critical Thinking/Analysis | Policy Translation | Quantitative Literacy -
Tutorial/PrimerPublication, Teaching Resource 2017Bayesian Methods for Calibrating Health Policy Models: A Tutorial
This article provides a tutorial on Bayesian approaches for model calibration. It describes the theoretical …
This article provides a tutorial on Bayesian approaches for model calibration. It describes the theoretical basis for Bayesian calibration approaches as well as pragmatic considerations that arise in the tasks of creating calibration targets, estimating the posterior distribution, and obtaining results to inform the policy decision. These considerations, as well as the specific steps for implementing the calibration, are described in the context of an extended worked example about the policy choice to provide (or…
Calibration/Validation | Infectious Diseases | Health/Medicine -
Tutorial/PrimerPublication, Teaching Resource 2015Economic Evaluations with Agent-Based Modelling: An Introduction
This tutorial presents the basic concepts and important features of agent-based models, and provides a …
This tutorial presents the basic concepts and important features of agent-based models, and provides a case study of a simple cost effectiveness analysis of screening for an infectious disease. Agent-based modelling (ABM) is a relatively new technique, which overcomes some of the limitations of other methods commonly used for economic evaluations. These limitations include linearity, homogeneity and stationarity. Agents in ABMs are autonomous entities, who interact with each other and with the environment. ABMs provide…
Dynamic Simulation | Mathematical Models | Infectious Diseases | Health/Medicine | Graduate | Doctoral | Professional | Conceptual Mapping | Quantitative Literacy -
Tutorial/PrimerPublication, Teaching Resource 2015Calibration of Complex Models through Bayesian Evidence Synthesis: A Tutorial
This tutorial demonstrates how to implement a Bayesian synthesis of diverse sources of evidence to …
This tutorial demonstrates how to implement a Bayesian synthesis of diverse sources of evidence to calibrate the parameters of a complex model. To illustrate these methods, the authors demonstrate how a previously developed Markov model for the progression of human papillomavirus (HPV-16) infection was rebuilt in a Bayesian framework. Transition probabilities between states of disease severity are inferred indirectly from cross-sectional observations of prevalence of HPV-16 and HPV-16–related disease by age, cervical cancer incidence, and…
Calibration/Validation | Infectious Diseases -
Tutorial/PrimerPublication, Teaching Resource 2005Refining Clinical Diagnosis with Likelihood Ratios
This article serves as a concise tutorial about the interpretation and use of likelihood ratios …
This article serves as a concise tutorial about the interpretation and use of likelihood ratios in clinical decision-making. Likelihood ratios can refine clinical diagnosis on the basis of signs and symptoms; however, they are underused for patients' care. A likelihood ratio is the percentage of ill people with a given test result divided by the percentage of well individuals with the same result. Ideally, abnormal test results should be much more typical in ill individuals…
Value of Information | Test Performance | Health/Medicine -
Tutorial/PrimerPublication, Teaching Resource 1980Threshold Approach to Clinical Decision Making
This classic paper provides a "tutorial" for students learning about diagnostic testing, probability revision, and …
This classic paper provides a "tutorial" for students learning about diagnostic testing, probability revision, and how to calculate thresholds for testing, treatment, and no treatment. The authors describe how a physician's estimate of the probability that a patient has a particular disease is a principal factor in the determination of whether to withhold treatment, obtain more data by testing, or treat without subjecting the patient to the risks of further diagnostic tests. Using the concepts of decision analysis,…
Value of Information | Probability/Bayes | Test Performance | Decision Analysis | Health/Medicine