Resources Repository
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ArticlePublication 2024Hypertension Care Cascades and Reducing Inequities in Cardiovascular Disease in LMIC
This study investigates the distributional implications of enhancing hypertension control in low- and middle-income countries …
This study investigates the distributional implications of enhancing hypertension control in low- and middle-income countries (LMICs) across wealth quintiles. Using individual-level data from nationally representative surveys in 44 LMICs, the researchers simulated improvements in the hypertension care cascade and assessed the distributional benefits. They raised diagnosis and treatment levels for all wealth quintiles to match the best-performing country quintile and estimated the resulting change in 10-year cardiovascular disease (CVD) risk. Results indicate greater health benefits…
Cost-Effectiveness Analysis | Health/Medicine | Chronic Disease/Risk -
ArticlePublication 2024Extended Cost-Effectiveness Analysis of Interventions to Improve Uptake of Diabetes Services in South Africa
This study examines the potential impact of a conditional cash transfer (CCT) program on diabetes …
This study examines the potential impact of a conditional cash transfer (CCT) program on diabetes diagnosis and treatment service utilization in South Africa (SA) using extended cost-effectiveness analysis (ECEA). Applying a Markov model over a 45-year period, the analysis compares costs, health benefits, and financial risk protection (FRP) attributes of different CCT strategies, drawing from SA-specific data. Three scenarios were simulated: covering diagnosis services only, treatment services only, and both diagnosis and treatment services. Cost-effectiveness,…
Cost-Effectiveness Analysis | Health/Medicine | Health Outcomes | Mathematical Models | Chronic Disease/Risk | Policy/Regulation | Sub-Saharan Africa -
Resource PackPublication, Teaching Resource 2023Resource Pack: Diagnostic Tests, Bayes, and COVID-19
This resource pack provides a curated set of articles, perspectives, and interactives about diagnostic testing …
This resource pack provides a curated set of articles, perspectives, and interactives about diagnostic testing for COVID-19. The pack provides materials that will be particularly useful for educators who are teaching diagnostic test performance, value of information, and probability revision using Bayes’ theorem. The majority of papers focus on PCR or rapid antigen testing on samples obtained from the respiratory tract by nasopharyngeal swab. The mechanism of false negative results (e.g., timing of sample collection…
Value of Information | Health/Medicine | Probability/Bayes | Test Performance | Decision Analysis | Science/Technology | Global | High School | College | Graduate | Doctoral | Professional | Critical Thinking/Analysis | Graphics/Visualization | Quantitative Literacy -
ExerciseNone, Teaching Resource 2024Lab: Autoimmune Encephalitis Decision Tree Model
This tutorial walks through the development of a decision tree model based on a published …
This tutorial walks through the development of a decision tree model based on a published cost-effectiveness analysis of routine screening for autoimmune encephalitis in patients with first-episode psychosis in the United States based on the published article: Ross EL, Becker JE, Linnoila JJ, Soeteman DI. Cost-Effectiveness of Routine Screening for Autoimmune Encephalitis in Patients with First-Episode Psychosis in the United States. J Clin Psychiatry 2020; 82 (1): 19m13168. The tutorial describes how to build the…
Cost-Effectiveness Analysis | Health/Medicine | Mathematical Models | Decision Analysis | Clinical Care | Graduate | Doctoral | Professional -
ArticlePublication 2023Cost-Effectiveness of Pharmacist Prescribing for Managing Hypertension
This study estimates the cost-effectiveness of implementing a pharmacist-prescribing intervention to improve blood pressure control …
This study estimates the cost-effectiveness of implementing a pharmacist-prescribing intervention to improve blood pressure control in the US. A cost-effectiveness analysis was conducted using a Markov model based on the pharmacist-prescribing intervention used in The Alberta Clinical Trial in Optimizing Hypertension (or RxACTION). Outcomes included cardiovascular (CV) events, end-stage kidney disease events, life years, quality-adjusted life years (QALYs), lifetime costs, and lifetime incremental cost-effectiveness ratio (ICER). Costs were based on reimbursement rates, published literature, national…
Cost-Effectiveness Analysis | Health/Medicine | Mathematical Models | State-Transition | Chronic Disease/Risk | Clinical Care | North America -
Resource PackWeb Portal, Teaching Resource 2023Resource Pack: Cost-Effectiveness of Screening and Treatment for Hypertension
Hypertension is a relevant example for teaching clinical decision making, diagnostic test performance, positivity criterion, …
Hypertension is a relevant example for teaching clinical decision making, diagnostic test performance, positivity criterion, and cost-effectiveness analysis. This resource pack provides examples of decision analyses and cost-effectiveness analyses for the management and treatment of hypertension, with a predominant focus on the U.S. Analyses are included that predate the 2017 American College of Cardiology/American Heart Association Clinical Practice Guidelines, along with more recent examples that followed release of the guidelines. Resources are also included that…
Cost-Effectiveness Analysis | Health/Medicine | Preferences/Values | Test Performance | Decision Analysis | Chronic Disease/Risk | Clinical Care | Economics/Finance | Science/Technology | North America | Europe | Graduate | Doctoral | Professional | Critical Thinking/Analysis | Policy Translation | Quantitative Literacy -
ArticlePublication 2021CEA of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals
Fecal occult blood testing with an immunochemical test (FIT) is generally considered as the most …
Fecal occult blood testing with an immunochemical test (FIT) is generally considered as the most cost-effective alternative in colorectal cancer screening programs for average risk individuals without family history. Colorectal screening guidelines recommend colonoscopy every 3-5 years for high-risk individuals with a family history. The authors use a microsimulation model of the natural history of colorectal cancer (CRC) to compare the costs, quality-adjusted life years, and cost effectiveness associated with several screening strategies in high-risk individuals,…
Cost-Effectiveness Analysis | Health/Medicine | Clinical Care -
Tutorial/PrimerPublication, Teaching Resource 2023Conducting Trial-Based Economic Evaluations Using R: A Tutorial
Trial-based economic evaluations are increasingly conducted to support healthcare decision-making but there are inevitable methodological …
Trial-based economic evaluations are increasingly conducted to support healthcare decision-making but there are inevitable methodological challenges. This tutorial provides step-by-step guidance on how to combine appropriate statistical methods using a ready-to-use R script, and addresses missing data, correlated costs and effects, baseline imbalances, and skewness of costs and/or effects. The authors also provide the theoretical background of these methods, and demonstrate their application through a simulated trial-based economic evaluation.
Evidence Synthesis | Health/Medicine | Costing Methods | Economics/Finance | Graduate | Doctoral | Professional | Quantitative Literacy -
ArticlePublication 2023Simulation-Based Estimates and Projections of Global, Regional and Country-Level Maternal Mortality by Cause, 1990-2050
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given …
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given the many causes and frequent underreporting of maternal deaths. The authors developed a structural microsimulation model of Global Maternal Health (GMatH) for 200 countries and territories using demographic, epidemiologic, clinical and health system data synthesized from the medical literature, Civil Registration Vital Statistics systems and Demographic and Health Survey data. The model was calibrated to empirical data from 1990 to…
Evidence Synthesis | Health/Medicine | Health Outcomes | Microsimulation | Calibration/Validation | Maternal/Reproductive Health | Health Systems | Clinical Care | Global