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- mathematical models
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Resources Repository
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BookPublication 2003WHO Guide to Cost-Effectiveness Analysis
This 2003 guide provides a method of assessing the cost-effectiveness of health interventions for an …
This 2003 guide provides a method of assessing the cost-effectiveness of health interventions for an international audience. The authors aim to inform the policy maker and to maximize the generalizability of results across settings. Part I begins with a description of cost-effectiveness analysis. It then considers issues relating to study design, estimating costs, assessing health effects, discounting, uncertainty and sensitivity analysis, and reporting results. Part II provides examples to illustrate the principles in Part I. Detailed discussions…
Evidence Synthesis | Mathematical Models | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Priority Setting/Ethics | Health Systems | Health/Medicine -
Working PaperPublication 2024Economic Evaluation Primer
Economic evaluation is a powerful tool, encouraging the systematic collection and assessment of the evidence …
Economic evaluation is a powerful tool, encouraging the systematic collection and assessment of the evidence needed to support sound policy decisions. In low- and middle-income countries, where resources are especially scarce and needs are very great, such decisions are exceptionally difficult. In these settings, economic evaluation can be particularly useful in determining how to best improve health and welfare. Typically, cost-effectiveness analysis (CEA) is used to prioritize interventions within the health care sector. This approach…
Benefit-Cost Analysis | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Priority Setting/Ethics | Policy/Regulation -
ArticlePublication 2023Simulation-Based Comparative Effectiveness Analysis of Policies to Improve Global Maternal Health Outcomes
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) …
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) to less than 70 maternal deaths per 100,000 live births by 2030, with no individual country exceeding 140. However, on current trends the goals are unlikely to be met. The authors used an empirically calibrated Global Maternal Health microsimulation model, which simulates individual women in 200 countries and territories to evaluate the impact of different interventions and strategies from 2022…
Microsimulation | Mathematical Models | Calibration/Validation | Health Outcomes | Global | Maternal/Reproductive Health | Health Systems | Clinical Care | Health/Medicine -
ArticlePublication 2023Simulation-Based Estimates and Projections of Global, Regional and Country-Level Maternal Mortality by Cause, 1990-2050
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given …
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given the many causes and frequent underreporting of maternal deaths. The authors developed a structural microsimulation model of Global Maternal Health (GMatH) for 200 countries and territories using demographic, epidemiologic, clinical and health system data synthesized from the medical literature, Civil Registration Vital Statistics systems and Demographic and Health Survey data. The model was calibrated to empirical data from 1990 to…
Evidence Synthesis | Microsimulation | Calibration/Validation | Health Outcomes | Global | Maternal/Reproductive Health | Health Systems | Clinical Care | Health/Medicine -
ArticlePublication 2010Alternative Strategies to Reduce Maternal Mortality in India: A Cost-Effectiveness Analysis
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy …
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy and childbirth safety in India. Country- and region-specific data were synthesized using a computer-based model that simulates the natural history of pregnancy and pregnancy-associated complications in individual women, and considers delivery location, attendant, and facility level. Model validation compared projected maternal indicators with empiric data. Strategies consisted of improving coverage of effective interventions that could be provided individually or packaged…
Evidence Synthesis | Microsimulation | Mathematical Models | Cost-Effectiveness Analysis | Global | Maternal/Reproductive Health | Economics/Finance | Health/Medicine | Asia & Pacific -
ReportPublication 2016DCP3: Reproductive, Maternal, Newborn, and Child Health
This report from the World Bank is the second volume of the Disease Control Priorities, …
This report from the World Bank is the second volume of the Disease Control Priorities, Third Edition (DCP3) series. It focuses primarily on maternal conditions, childhood illnesses, and malnutrition, addressing topics from maternal mortality and morbidity, to acute illness and undernutrition in children under five, to the transition to older childhood and the illnesses that accompany this transition. The Disease Control Priorities Network (DCP) promotes and supports the use of economic evaluation for priority setting…
Evidence Synthesis | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Maternal/Reproductive Health | Child/Nutrition | Health Systems | Global Governance | Economics/Finance | Health/Medicine -
ReportPublication 2017DCP3: Child and Adolescent Health and Development
This report from the World Bank is the eighth volume of the Disease Control Priorities, …
This report from the World Bank is the eighth volume of the Disease Control Priorities, Third Edition (DCP3) series and focuses on the health and well-being of children and adolescents, ages 5 to 21, worldwide. It provides estimates of mortality and morbidity among youth, examines the impact of interventions during that period on health and development, features successful community- and school-based health and nutrition interventions, reports on platforms that promote early childhood development, and highlights…
Evidence Synthesis | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Child/Nutrition | Social Determinants | Global Governance | Economics/Finance | Health/Medicine -
ReportPublication 2017DCP3: Cardiovascular, Respiratory, and Related Disorders
This report from the World Bank is the fifth volume of the Disease Control Priorities, …
This report from the World Bank is the fifth volume of the Disease Control Priorities, Third Edition (DCP3) series. It addresses the disease burden of cardiovascular, respiratory, and related disorders (CVRDs), which account for more than half of global adult deaths, mostly in low- and middle-income countries. While CVRDs are mostly preventable or can be treated to reduce morbidity, such interventions are costly and require greater capacity to detect and treat early. When combined with…
Evidence Synthesis | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Chronic Disease/Risk | Social Determinants | Health Systems | Global Governance | Climate/Environment | Health/Medicine -
ReportPublication 2016DCP3: Mental, Neurological, and Substance Use Disorders
This report from the World Bank is the fourth volume of the Disease Control Priorities, …
This report from the World Bank is the fourth volume of the Disease Control Priorities, Third Edition (DCP3) series. It discusses the prevalence of mental, neurological, and substance use disorders, as well as the associated disability and premature mortality that can accompany them. Despite the high social and economic burden of these diseases on individuals, families, and communities, these disorders have been systematically neglected, especially in low- and middle-income countries, and there has been limited…
Evidence Synthesis | Cost-Effectiveness Analysis | Costing Methods | Health Outcomes | Global | Mental Health | Health Systems | Global Governance | Economics/Finance | Health/Medicine