Resources Repository
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ArticlePublication 2011Health and Economic Impact of HPV 16/18 Vaccination and Cervical Cancer Screening in Eastern Africa
In this article the authors use epidemiologic data from Kenya, Mozambique, Tanzania, Uganda, and Zimbabwe …
In this article the authors use epidemiologic data from Kenya, Mozambique, Tanzania, Uganda, and Zimbabwe to develop models of HPV-related infection and disease. For each country, they assessed HPV vaccination of girls before age 12 followed by screening with HPV DNA testing once, twice, or three times per lifetime (at ages 35, 40, 45). For women over age 30, they assessed only screening (with HPV DNA testing up to three times per lifetime or VIA…
Science/Technology | Microsimulation | Calibration/Validation | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Clinical Care | Economics/Finance | Health/Medicine | Sub-Saharan Africa -
ArticlePublication 2008Health and Economic Impact of HPV 16 and 18 Vaccination and Cervical Cancer Screening in India
As cervical cancer is a leading cause of cancer death among women in low-income countries, …
As cervical cancer is a leading cause of cancer death among women in low-income countries, with approximately 25% of cases worldwide occurring in India, these authors estimated the potential health and economic impact of different cervical cancer prevention strategies in India. After empirically calibrating a cervical cancer model to country-specific epidemiologic data, they projected cancer incidence, life expectancy, and lifetime costs (I$2005), and calculated incremental cost-effectiveness ratios (I$/YLS) for the following strategies: pre-adolescent vaccination of…
Science/Technology | Microsimulation | Calibration/Validation | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Health Systems | Clinical Care | Economics/Finance | Health/Medicine | Asia & Pacific -
ArticlePublication 2007Modeling HPV and Cervical Cancer in the U.S. for Analyses of Screening and Vaccination
This paper discusses a model of human papillomavirus (HPV) and cervical cancer that incorporates uncertainty …
This paper discusses a model of human papillomavirus (HPV) and cervical cancer that incorporates uncertainty about the natural history of disease that was used to provide quantitative insight into U.S. policy choices for cervical cancer prevention. The authors developed a stochastic microsimulation of cervical cancer that distinguishes different HPV types by their incidence, clearance, persistence, and progression. For each set of sampled input parameters, likelihood-based goodness-of-fit (GOF) scores were computed based on comparisons between model-predicted…
Science/Technology | Microsimulation | Calibration/Validation | Infectious Diseases | Chronic Disease/Risk | Clinical Care | Health/Medicine | North America -
ReviewPublication 2006Ethical Issues in Resource Allocation, Research, and New Product Development
Ethical dilemmas arising in setting priorities among interventions and among individuals in need of care …
Ethical dilemmas arising in setting priorities among interventions and among individuals in need of care are most acute when needs are great and resources few. This chapter from the Disease Control Priorities in Developing Countries 2nd edition addresses some of these concerns, identifying some of the principal ethical issues that arise in the development and allocation of effective interventions for developing countries and discussing some alternative resolutions. Resource allocation in health and elsewhere should satisfy two main…
Priority Setting/Ethics | Science/Technology | Preferences/Values | Cost-Effectiveness Analysis | Culture/Society | Government/Law | Health/Medicine -
ReviewPublication 1982Decision Analysis: An Overview
This article, written for the non-decision analyst, describes what decision analysis is, what it can …
This article, written for the non-decision analyst, describes what decision analysis is, what it can and cannot do, why one should care to do this, and how one does it. Keeney describes decision analysis as "a formalization of common sense for decision problems which are too complex for informal use of common sense." He provides a more technical definition also, describing decision analysis as "a philosophy, articulated by a set of logical axioms, and a methodology…
Science/Technology | Decision Theory | Preferences/Values | Decision Analysis | Policy/Regulation | Business/Industry | Economics/Finance | Energy/Engineering | Government/Law | Health/Medicine | Military/Defense -
ArticlePublication 2022Estimated Transmission Outcomes and Costs of SARS-CoV-2 Diagnostic Testing, Screening, and Surveillance Strategies Among a Simulated Population of Primary School Students
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 …
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 billion in March 2021 for testing in schools. The study aimed to analyze the costs and benefits of different COVID-19 testing strategies, particularly focusing on full-time, in-person elementary and middle school education. Utilizing an updated agent-based network model, the study simulated transmission scenarios in schools, considering various testing strategies ranging from diagnostic testing (test-to-stay) to reduce symptom-based isolations, routine screening…
Science/Technology | Test Performance | Mathematical Models | Cost-Effectiveness Analysis | Infectious Diseases | Clinical Care | Health/Medicine | North America -
ArticlePublication 2021Emotion and Humor as Misinformation Antidotes
Many visible public debates over scientific issues are clouded in accusations of falsehood, which place …
Many visible public debates over scientific issues are clouded in accusations of falsehood, which place increasing demands on citizens to distinguish fact from fiction. Yet, constraints on our ability to detect misinformation coupled with our inadvertent motivations to believe false science result in a high likelihood that we will form misperceptions. As science falsehoods are often presented with emotional appeals, the authors focus their perspective on the roles of emotion and humor in the formation…
Science/Technology | Decision Psychology | Culture/Society | North America -
ArticlePublication 2018Motivational Interviewing: A Promising Tool to Address Vaccine Hesitancy
In most countries, there is an increase in ‘‘vaccine hesitancy,” defined as the proportion of …
In most countries, there is an increase in ‘‘vaccine hesitancy,” defined as the proportion of parents who refuse some, many, or all vaccines or who adopt a delayed vaccination schedule, regardless of the availability of vaccination services. Generally, approaches to address vaccine hesitancy suggest either strong policies of mandatory immunization or more traditional approaches of education and information. Although mandatory immunization policies may increase uptake of vaccines, they do not address the root causes of…
Science/Technology | Preferences/Values | Infectious Diseases | Social Determinants | Culture/Society | Government/Law | Health/Medicine | North America -
ArticlePublication 1964Epidemics and Rumors
Goffman and Newill directed attention to the analogy between the spreading of an infectious disease …
Goffman and Newill directed attention to the analogy between the spreading of an infectious disease and the dissemination of information. This article examines the spreading of a rumor from the point of view of mathematical epidemiology and briefly reports on work to be published in detail elsewhere. Authors emphasize that a mathematical model for the spreading of rumors can be constructed in a number of different ways, depending on the mechanism postulated to describe the…
Science/Technology | Preferences/Values | Infectious Diseases | Culture/Society | Health/Medicine | Global