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Resources Repository
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ArticlePublication 2020Testing for SARS-CoV-2 Antibodies
Antibody testing can determine previous exposure to SARS-CoV-2 virus. Recently, the UK government has made …
Antibody testing can determine previous exposure to SARS-CoV-2 virus. Recently, the UK government has made antibody testing available to anyone wanting it, even if there is no clinical indication. The purpose of this article is to provide guidance for when to consider antibody testing in individuals with and without symptoms suggestive of current or past SARS-CoV-2 infection. Key points made by the authors include: (1) antibody testing is likely to be most useful 2 weeks…
Probability/Bayes | Test Performance | Technology Assessment | Health/Medicine | Infectious Diseases | Clinical Care -
EditorialPublication 2020Waiting for Certainty on COVID-19 Antibody Tests — At What Cost?
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation …
This perspective anticipates the availability of serologic antibody testing and considers its potential usefulness in mitigation policy to reduce COVID-19 transmission. For example: Could we screen for serologic antibodies as a proxy for possible immunity and identify people who could return to the workplace with less severe mitigation measures? The authors acknowledge the uncertainties raised by many policy actors, including the WHO, such as, "Do antibodies confer immunity and, if so, for how long? How accurate is…
Probability/Bayes | Test Performance | Technology Assessment | Health/Medicine | Infectious Diseases | Health Systems | Policy/Regulation | Government/Law | Global | North America -
ArticlePublication 2020Expanding Oral Disease Treatment is Cost Effective
This study developed a stochastic microsimulation model of oral health conditions, type-2 diabetes (T2D), T2D-related …
This study developed a stochastic microsimulation model of oral health conditions, type-2 diabetes (T2D), T2D-related microvascular diseases, and CVD, to project the cost-effectiveness of expanding periodontal treatment coverage among patients with T2D and periodontitis. Previous randomized trials found that treating periodontitis improved glycemic control in patients with type 2 diabetes (T2D), thus lowering the risks of developing T2D-related microvascular diseases and cardiovascular disease (CVD). The micro-simulation model parameters were obtained from the nationally representative National…
Mathematical Models | Cost-Effectiveness Analysis | Calibration/Validation | Health/Medicine | Microsimulation | Chronic Disease/Risk | North America | Graduate -
Teaching PackPublication, Teaching Resource 2022Teaching Pack: Probability Revision and Bayes
In this teaching pack on Probability Revision and Bayes, students are introduced to the implications …
In this teaching pack on Probability Revision and Bayes, students are introduced to the implications of imperfect information, acquire a conceptual understanding of Bayes theorem, and gain practical skills in performing probability revision. Materials include an instructor's note, videos, companion slides, a glossary, an annotated bibliography, sample exercises, and additional support. Learning Objectives Demonstrate a conceptual understanding of Bayes’ theorem and probability revision. Differentiate between test characteristics (e.g., probability of positive test given…
Probability/Bayes | Test Performance | Decision Analysis | Health/Medicine | Environmental Health | College | Graduate | Critical Thinking/Analysis | Graphics/Visualization | Quantitative Literacy -
Teaching PackPublication, Teaching Resource 2022Teaching Pack: Using Test Information I
In this teaching pack on Using Test Information I, students review the performance of a …
In this teaching pack on Using Test Information I, students review the performance of a dichotomous test and the relationship between sensitivity and specificity, calculate likelihood ratios to describe test performance, and conduct probability revision using the odds-LR form of Bayes. Materials include an instructor's note, videos, companion slides, a glossary, an annotated bibliography, and sample exercises. Learning Objectives Calculate four conditional probabilities describing the performance of a dichotomous test, and explain the…
Probability/Bayes | Test Performance | Decision Analysis | Health/Medicine | Child/Nutrition | College | Graduate | Doctoral | Professional | Critical Thinking/Analysis | Graphics/Visualization | Quantitative Literacy -
Teaching PackPublication, Teaching Resource 2022Teaching Pack: Using Test Information II
In this teaching pack on Using Test Information II, students are introduced to tests with …
In this teaching pack on Using Test Information II, students are introduced to tests with continuous or categorical results, and calculate the sensitivity and specificity conditional on different 'cutoff points' or 'positivity criterion'. They are introduced to ROC curves and explore the implications of operating at different parts of the curve for any single test. They calculate the optimal positivity criterion given information on the prior, the test performance, and the relative consequences of true…
Probability/Bayes | Test Performance | Decision Analysis | Health/Medicine | College | Graduate | Doctoral | Critical Thinking/Analysis | Quantitative Literacy -
ReviewPublication 2017Patients' Preferences in Cancer Treatment: Review of Discrete Choice Experiments
This study aimed to systematically review discrete choice experiments (DCEs) about patients’ preferences for cancer …
This study aimed to systematically review discrete choice experiments (DCEs) about patients’ preferences for cancer treatment and assessed the relative importance of outcome, process and cost attributes. A systematic literature review was conducted using PubMed and EMBASE to identify all DCEs investigating patients’ preferences for cancer treatment between January 2010 and April 2016. Attributes were classified into outcome, process and cost attributes, and their relative importance was assessed. A total of 28 DCEs were identified.…
Preferences/Values | Cost-Effectiveness Analysis | Decision Analysis | Health/Medicine | Health Outcomes | Chronic Disease/Risk | Health Systems | Economics/Finance | North America | Europe -
ArticlePublication 2017Designing an Optimal HIV Programme for South Africa
This 2017 study compares the traditional and a novel method of comparing cost-effectiveness interventions in …
This 2017 study compares the traditional and a novel method of comparing cost-effectiveness interventions in the context of HIV in South Africa, using a modeling approach. The authors argue that the assumptions of a) independence of interventions, and b) linear scale-up effects do not hold because South Africa has a large domestically funded HIV program with highly saturated coverage levels. The authors therefore aim to better allocate resources for HIV interventions in South Africa when…
Mathematical Models | Operations Research | Cost-Effectiveness Analysis | Health/Medicine | Priority Setting/Ethics | Infectious Diseases | Health Systems | Economics/Finance | Sub-Saharan Africa -
Resource PackPublication, Teaching Resource 2017Resource Pack: CEA Herpes Zoster Vaccine
This resource pack on the cost-effectiveness of herpes zoster vaccination was curated to support Dr. …
This resource pack on the cost-effectiveness of herpes zoster vaccination was curated to support Dr. Lisa Prosser's seminar on November 9, 2017 at the Center for Health Decision Science. Dr. Prosser discussed an economic evaluation of vaccination against herpes zoster. Herpes zoster—more commonly known as shingles—presents a major burden for older Americans but, until recently, the only available vaccine (Zoster Vaccine Live, ZVL) was relatively ineffective past 10 years. A recently approved vaccine–herpes zoster subunit…
Preferences/Values | Mathematical Models | Cost-Effectiveness Analysis | Health/Medicine | Costing Methods | Health Outcomes | Infectious Diseases | Clinical Care | Culture/Society | Science/Technology | North America | Europe