Resources Repository
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ReviewPublication 2001Modeling for Health Care and Other Policy Decisions: Uses, Roles and Validity
This is a review article of the role of modeling approaches to guide decision making …
This is a review article of the role of modeling approaches to guide decision making in health care and other domains. The role of models to support recommendations on the cost-effective use of medical technologies and pharmaceuticals is controversial. At the heart of the controversy is the degree to which experimental or other empirical evidence should be required prior to model use. The authors argue that the controversy stems in part from a misconception that…
Evidence Synthesis | Priority Setting/Ethics | Mathematical Models | Technology Assessment | Environmental Health | Health Systems | Policy/Regulation | Business/Industry | Climate/Environment | Economics/Finance | Energy/Engineering | Government/Law | Health/Medicine | North America -
BookPublication 1996Cost-Effectiveness in Health and Medicine, 1st Edition
In 1993, the US Public Health Service convened a panel of 13 nongovernment scientists and …
In 1993, the US Public Health Service convened a panel of 13 nongovernment scientists and scholars with expertise in economics, clinical medicine, ethics, and statistics to review the state of cost-effectiveness analysis and to develop recommendations for its conduct and use in health and medicine. Publishing their results in 1996, they proposed the most explicit set of guidelines (together with their rationale) ever defined on the conduct of CEAs. The panel recommended analysts include a "reference-case"…
Evidence Synthesis | Priority Setting/Ethics | Preferences/Values | Costing Methods | Health Outcomes | Value of Information | Cost-Effectiveness Analysis | Health Systems | Policy/Regulation | Economics/Finance | Health/Medicine | North America -
Tutorial/PrimerPublication, Teaching Resource 2024Tutorial: Building Decision Trees
This tutorial illustrates the basic steps needed to develop decision trees in Amua using a …
This tutorial illustrates the basic steps needed to develop decision trees in Amua using a disease screening example. It details the process of how to build the structure of a decision tree, parameterize the model with probabilities and relevant outcomes (i.e., life expectancy), evaluate three alternative screening strategies in a baseline scenario, and perform one-way sensitivity analyses to assess the robustness of the results to different parameter values. Amua, the Swahili word meaning “decide”/“solve”, is…
Probability/Bayes | Mathematical Models | Decision Analysis | Clinical Care | Health/Medicine | Graduate | Doctoral | Professional -
ReportPublication 2023Roadmap for Increasing the Usefulness and Impact of Patient-Preference Studies in Decision Making in Health
This ISPOR Task Force report examines the integration of patient preferences into healthcare decision-making, emphasizing …
This ISPOR Task Force report examines the integration of patient preferences into healthcare decision-making, emphasizing the growing significance of both qualitative and quantitative methods for studying these preferences. The report synthesizes current best practices to enhance the utility and impact of patient-preference studies. The methods involved reviewing existing literature and practices to construct the ISPOR Roadmap for Patient Preferences in Decision Making. This roadmap encourages collaboration among researchers, decision-makers, patients, patient groups, and other stakeholders.…
Evidence Synthesis | Preferences/Values | Health Outcomes | Health/Medicine -
ReviewPublication 2023Systematic Review of Cost-Effectiveness Studies of Newer Non-Insulin Antidiabetic Drugs: Trends in Decision-Analytical Models for Modelling of Type 2 Diabetes Mellitus
This systematic review analyzed cost-effectiveness analyses (CEAs) using decision-analytical modeling (DAM) to compare non-insulin antidiabetic …
This systematic review analyzed cost-effectiveness analyses (CEAs) using decision-analytical modeling (DAM) to compare non-insulin antidiabetic drugs (NIADs) within glucagon-like peptide-1 (GLP1) receptor agonists, sodium-glucose cotransporter-2 (SGLT2) inhibitors, or dipeptidyl peptidase-4 (DPP4) inhibitors for treating type 2 diabetes mellitus (T2DM). The study focused on economic results and underlying methodological choices. Methods included searching PubMed, Embase, and Econlit databases from January 1, 2018, to November 15, 2022. Two reviewers screened titles, abstracts, and full texts for relevance…
Evidence Synthesis | Mathematical Models | Cost-Effectiveness Analysis | Chronic Disease/Risk | Health/Medicine | Europe -
ReviewPublication 2023Economic & Humanistic Burden of Osteoarthritis: Systematic Review of Large Sample Studies
This study systematically reviewed and updated the economic and humanistic burden of osteoarthritis (OA) reported …
This study systematically reviewed and updated the economic and humanistic burden of osteoarthritis (OA) reported by large sample studies since 2016. Medline (via Ovid) and Embase were searched using an updated strategy based on a previous review. Studies with a sample size ≥1000 that measured direct or indirect costs or health-related quality of life (HRQL) of OA were included. Pairs of reviewers independently screened studies, and an arbitrator resolved discrepancies. The Kappa value for agreement…
Evidence Synthesis | Preferences/Values | Cost-Effectiveness Analysis | Chronic Disease/Risk | Health/Medicine | Global -
ArticlePublication 2023Designing Guidelines for Those Who Do Not Follow Them: Impact of Adherence Assumptions on Optimal Screening Guidelines
This study examines the impact of real-world screening adherence on the cost-effectiveness of cervical cancer …
This study examines the impact of real-world screening adherence on the cost-effectiveness of cervical cancer screening guidelines. Using a microsimulation model of cervical carcinogenesis, the researchers projected long-term health and economic outcomes for 18 screening algorithms under various adherence scenarios. These included perfect adherence, eight high- and low-coverage "random-complier" scenarios, and three "systematic-complier" scenarios reflecting conditional screening behavior over a lifetime. Results showed that perfect adherence favored the least intensive screening strategy, while any level…
Microsimulation | Mathematical Models | Cost-Effectiveness Analysis | Chronic Disease/Risk | Health/Medicine -
ReviewPublication 2023Systematic Literature Review of Gaps and Challenges in Value Assessment of Biosimilars: ISPOR Special Interest Group Report
This study addresses the gaps and challenges in the value assessment of biosimilars and proposes …
This study addresses the gaps and challenges in the value assessment of biosimilars and proposes potential approaches to mitigate them. A multidisciplinary team of biosimilar experts conducted a systematic review of literature and engaged in review rounds to identify these challenges. The article suggests that health technology assessment agencies should accept the comparability exercise approved by regulatory authorities and conduct price comparisons for biosimilars reimbursed for the same indication as the reference biologic. In cases…
Evidence Synthesis | Preferences/Values | Technology Assessment | Policy/Regulation | Health/Medicine -
ReviewPublication 2023How Values Are Discussed, Reflected Upon, and Acted on by Patients and Family Caregivers in the Context of Heart Failure: Scoping Review
The study examines how values influence decision-making and coping among heart failure (HF) patients and …
The study examines how values influence decision-making and coping among heart failure (HF) patients and their family caregivers (FCGs). Through a scoping review of 16 empirical studies, patient values were found to influence self-care behaviors and left ventricular assist device (LVAD) implantation decisions, with variations in prioritization over time and contexts. Conflicts between prioritized values and recommended self-care activities led to modifications in behavior. Patient survival emerged as a top value during cardiac device decisions.…
Evidence Synthesis | Preferences/Values | Decision Psychology | Chronic Disease/Risk | Health/Medicine