Resources Repository
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ArticlePublication 2020Post-Heart Transplantation Diabetes Mellitus
This retrospective study analyzed glycemic trends, incidence of post-transplant diabetes mellitus (PTDM), and associated risk …
This retrospective study analyzed glycemic trends, incidence of post-transplant diabetes mellitus (PTDM), and associated risk factors in a cohort of patients who underwent first-time heart transplantation. Univariate analyses compared patients with and without pretransplant diabetes mellitus. Multivariate regression analyses determined the association between PTDM and different risk factors. Finally, trends in glucometrics and other outcomes are described across follow-up time points.
Health/Medicine | Chronic Disease/Risk | North America -
ArticlePublication 2020Post-Transplantation Diabetes Incidence and Risk Factors
Most prior studies characterizing post-transplantation diabetes mellitus have been limited to single-cohort, single-organ studies. This …
Most prior studies characterizing post-transplantation diabetes mellitus have been limited to single-cohort, single-organ studies. This retrospective study determined post-transplantation diabetes mellitus across organs by comparing incidence and risk factors among 346 liver and 407 kidney transplant recipients from a single center. The authors used univariate and multivariate regression-based analyses to determine the association of various risk factors and post-transplantation diabetes mellitus in the two cohorts, as well as differences in glucometrics and insulin use across…
Health/Medicine | Chronic Disease/Risk | North America -
ArticlePublication 2022Cost-Effectiveness of Masked Hypertension Screening and Treatment
The study assessed the health and economic outcomes of screening and treating masked hypertension in …
The study assessed the health and economic outcomes of screening and treating masked hypertension in U.S. adults using the Cardiovascular Disease (CVD) Policy Model, a microsimulation model. The model simulated 100,000 adults suspected of having masked hypertension (office blood pressure [BP] of 120–129/<80 mm Hg, not on antihypertensive medications, and without a history of CVD). Interventions included: usual care alone, usual care with ambulatory BP monitoring (ABPM), and usual care with home BP monitoring (HBPM).…
Health/Medicine | Chronic Disease/Risk | Microsimulation | Cost-Effectiveness Analysis | Clinical Care | North America -
ArticlePublication 2022Duration & Cost-Effectiveness of Hepatocellular Carcinoma Surveillance in Hepatitis C Patients After Viral Eradication
This study assesses the cost-effectiveness of biannual surveillance for hepatocellular carcinoma (HCC) in patients cured …
This study assesses the cost-effectiveness of biannual surveillance for hepatocellular carcinoma (HCC) in patients cured of hepatitis C virus (HCV) using oral direct-acting antivirals (DAAs). A microsimulation model of HCC natural history in individuals with HCV-related advanced fibrosis or cirrhosis post-DAAs was developed, integrating data on HCC incidence, tumor progression, surveillance adherence, and health state costs/utilities. Biannual ultrasound and alpha-fetoprotein surveillance were compared to no surveillance over varying durations (5 years to lifetime). Results indicate…
Health/Medicine | Chronic Disease/Risk | Microsimulation | Cost-Effectiveness Analysis | North America -
ArticlePublication 2022Cost-Effectiveness & Value-of-Information Analysis Using Machine Learning-Based Metamodeling: A Case of Hepatitis C Treatment
This study compares machine learning (ML)-based metamodels with conventional metamodeling approaches in replicating the outcomes …
This study compares machine learning (ML)-based metamodels with conventional metamodeling approaches in replicating the outcomes of a complex simulation model of hepatitis C virus (HCV) natural history. Three ML-based metamodels (random forest, support vector regression, and artificial neural networks) and a linear regression-based metamodel were developed from the simulation model's 40 input parameters. Performance evaluation included root mean squared error (RMSE) and Pearson's R2 on normalized data. ML-based metamodels generally outperformed linear regression, with random…
Health/Medicine | Chronic Disease/Risk | Mathematical Models | Infectious Diseases -
ArticlePublication 2022Cost-Effectiveness of Screening for Atrial Fibrillation Using Wearable Devices
This economic evaluation assesses the cost-effectiveness of atrial fibrillation (AF) screening strategies, particularly utilizing wrist-worn …
This economic evaluation assesses the cost-effectiveness of atrial fibrillation (AF) screening strategies, particularly utilizing wrist-worn wearable devices, to prevent strokes. Conducted using a microsimulation decision-analytic model, the study spans from September 8, 2020, to May 23, 2022, incorporating 30 million simulated individuals representative of the US population aged 65 years or older. Eight screening strategies, including six employing wrist-worn devices and two using traditional methods, were compared against no screening. Results indicate that all wrist-worn…
Health/Medicine | Chronic Disease/Risk | Microsimulation | Cost-Effectiveness Analysis | North America -
ArticlePublication 2020Infectious Disease Pandemic Planning and Response: Incorporating Decision Analysis
During a pandemic, decisions must be made under rapidly changing, uncertain conditions. Despite advances in …
During a pandemic, decisions must be made under rapidly changing, uncertain conditions. Despite advances in analytical methods for gaining early situational awareness (i.e., of a disease’s transmissibility and severity) and for predicting the likely effectiveness of interventions, a major gap exists globally in terms of integrating this information in policy documents. The authors argue that mathematical and statistical models are important tools for pandemic planning and response. Once an outbreak of pandemic potential has been…
Health/Medicine | Health Systems | Mathematical Models | Decision Analysis | Government/Law | Global -
ArticlePublication 2021Cost-Effectiveness of Hypertension Treatment by Pharmacists in Black Barbershops
The Los Angeles Barbershop Blood Pressure Study (LABBPS) examined the effectiveness and cost of a …
The Los Angeles Barbershop Blood Pressure Study (LABBPS) examined the effectiveness and cost of a one-year pharmacist-led hypertension care intervention in Black-owned barbershops in Los Angeles County, focused on non-Hispanic Black men with uncontrolled hypertension. Using a discrete event simulation, the researchers projected the 10-year health outcomes and health care costs associated with the intervention compared to a control group. The costs and quality-adjusted life-years (QALYs) were calculated from a health care sector perspective, with…
Health/Medicine | Chronic Disease/Risk | Mathematical Models | Cost-Effectiveness Analysis | Clinical Care | North America -
OrganizationWeb Portal 2024Public Health Communications Collaborative
The COVID-19 pandemic has powerfully demonstrated the critical need for public health protections. Misinformation and …
The COVID-19 pandemic has powerfully demonstrated the critical need for public health protections. Misinformation and conflicting messages about COVID-19 have confused Americans and eroded trust in public health organizations. Maintaining and strengthening the credibility of these organizations at the federal, state, and local levels is critical to making communities healthier and ultimately saving lives. The Public Health Communications Collaborative (PHCC) was formed in 2020 to coordinate and amplify public health messaging on COVID-19 and increase…
Health/Medicine | Health Systems | Social Determinants | Policy/Regulation | Culture/Society | Science/Technology | North America