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ArticlePublication 2012Estimated Benefits of Atypical Antipsychotics in Schizophrenia: A Decision Model
This article, published in Annals of General Psychiatry, describes the development of a decision tree model …
This article, published in Annals of General Psychiatry, describes the development of a decision tree model with Markov processes to quantify the resources used and the corresponding burden of disease due to a projected reduction in relapse frequency resulting from further improvements in medication compliance in patients with schizophrenia. The analyses are conducted from the third party payer perspective and outcomes are modeled over a one-year and five-year time horizon. Three delivery technologies are compared: a…
State-Transition | Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ReviewPublication 2017Model-Based Economic Evaluation of Treatments for Depression: A Systematic Review
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies …
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies evaluating the cost-effectiveness of treatments for depression and examine the appropriateness of different modelling technique for simulating the natural course of depression. The review yielded 41 model-based studies, of which 21 used decision trees (DTs), 15 used cohort-based state-transition Markov models (CMMs), two used individual-based state-transition models (ISMs), and three used discrete-event simulation (DES) models. Just over half of the…
State-Transition | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ReviewPublication 2012A Critical Review of Model-Based Economic Studies of Depression
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The …
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The strengths and limitations of different modeling techniques and the factors influencing the choice for a specific modeling technique is discussed. The authors also address the appropriateness of model structure and data sources used to populate the models. This review identifies fourteen model-based studies including 8 studies that developed decision trees, 5 studies used Markov models, and one study a Markov…
State-Transition | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2006Model to Assess the Cost-Effectiveness of New Treatments for Depression
This article, published in the International Journal of Technology Assessment in Health Care, describes a …
This article, published in the International Journal of Technology Assessment in Health Care, describes a Markov model to compare the cost-effectiveness of a hypothetical new treatment for depression with standard care. Data on costs, quality of life and transition probabilities are derived from the observational Health Economic Aspects of Depression in Sweden (HEADIS) study. Data on long-term consequences of depression and mortality risks are obtained from the published literature. The analyses are conducted from the…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2010Cost-Effectiveness of Improved Primary Care Treatment of Depression in Women in Chile
This article, published in the British Journal of Psychiatry, describes a modified version of a …
This article, published in the British Journal of Psychiatry, describes a modified version of a previously developed Markov cohort model to compare the cost-effectiveness of usual care and improved stepped care among women with major depression in Chile. The lifetime cost-effectiveness results are measured in international dollars per quality-adjusted life year (I$/QALY). This international dollar takes into account the purchasing power parity of each country. The incremental cost-effectiveness ratio (ICER) of usual care is $113…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Latin America & Caribbean -
ArticlePublication 2006Costs & Benefits of Enhanced Depression Care to Employers
This article, published in the Archives of General Psychiatry, aims to estimate the cost-effectiveness of …
This article, published in the Archives of General Psychiatry, aims to estimate the cost-effectiveness of a program of enhanced depression care, specifically for workers compared to usual care from the societal perspective in a cohort of 40-year-old employees in the US. The authors also conduct a cost-benefit analysis from the perspective of the employer-purchaser over a 5-year time frame. From the societal perspective, the results indicate that screening and depression care management for workers…
State-Transition | Benefit-Cost Analysis | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ArticlePublication 2015Cost-Effectiveness of Transcranial Magnetic Stimulation vs. Antidepressants
This article, published in Value in Health, describes the development of a Markov model to …
This article, published in Value in Health, describes the development of a Markov model to compare the cost-effectiveness of repetitive transcranial magnetic stimulation (rTMS) therapy with pharmacotherapy for the treatment of patients with treatment-resistant major depressive disorder. Pharmacotherapy includes selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, tricyclics, noradrenergic and specific serotonergic antidepressants, and monoamine oxidase inhibitors. Data on model input parameters are obtained from published literature, national cost reports, and expert opinions. Analyses…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Oceania -
ArticlePublication 2016Cost-Effectiveness of Collaborative Care for Depression and Comorbid Diabetes or CVD
This article, published in BMJ Open, presents an economic model that combines a decision tree …
This article, published in BMJ Open, presents an economic model that combines a decision tree and a Markov cohort model to investigate the long-term cost-effectiveness of collaborative care versus usual care for individuals with depression and comorbid diabetes and/or cardiovascular disease. Data from the COINCIDE trial informs the model input parameters. The COINCIDE trial is a randomized controlled trial of collaborative care versus usual care that enrolled 387 participants from 36 primary care general practices…
State-Transition | Cost-Effectiveness Analysis | Chronic Disease/Risk | Mental Health | Health/Medicine | Europe -
ArticlePublication 2006Can Discrete Event Simulation be of Use in Modeling Major Depression?
This article, published in Cost Effectiveness and Resource Allocation, reviews the published literature on Markov …
This article, published in Cost Effectiveness and Resource Allocation, reviews the published literature on Markov models in depression and identified potential limitations in using this particular modelling approach in this disease area. Additionally, the authors develop a “Discrete Event Simulation” (DES) model to investigate the benefits and drawbacks of this simulation method compared with Markov modelling techniques. The findings of this study indicate that the most important limitation of using Markov models in depression is…
State-Transition | Microsimulation | Decision Analysis | Mental Health | Health/Medicine -
ArticlePublication 2011Cost-Effectiveness of Aripiprazole versus Olanzapine in Schizophrenia and Bipolar Disorder
This article, published in Acta Psychiatrica Scandinavica, describes a Markov model that estimates the cost-effectiveness …
This article, published in Acta Psychiatrica Scandinavica, describes a Markov model that estimates the cost-effectiveness of aripiprazole versus olanzapine in the treatment of patients with schizophrenia or bipolar disorder in Sweden with a focus on the metabolic impact of the treatments. The health-state transition model consists of five health states: no metabolic syndrome, metabolic syndrome, diabetes, coronary heart disease, and death. The analyses are conducted over a lifetime, with a cycle length of one year.…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2014Cost-Effectiveness of Asenapine in the Treatment of Bipolar Disorder in Canada
This article, published in BMC Psychiatry, presents a decision tree combined with a Markov model …
This article, published in BMC Psychiatry, presents a decision tree combined with a Markov model that estimates the cost-effectiveness of asenapine compared with olanzapine in the treatment of bipolar disorder in Canada. The decision tree part of the model takes into account the occurrence of extrapyramidal symptoms, the probability of switching to a different antipsychotic, and the probability of gaining weight. The Markov model part takes into account the long-term metabolic complications including diabetes, hypertension,…
State-Transition | Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ReviewPublication 2014Systematic Review of Model-Based Economic Evaluations of Drugs in Bipolar Disorder
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature …
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature on model-based economic evaluations of pharmacotherapeutics in patients with bipolar disorders. This review identifies 14 studies. Of these 14 studies, nine use Markov, three use discrete-event simulation (DES) and two use decision-tree models. Most of the studies (n = 11) do not include the rationale for the choice of modelling technique undertaken. Half of the studies do not include the…
State-Transition | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2008Modelling Approaches: The Case of Schizophrenia
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using …
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using both cohort and microsimulation approaches) and discrete event simulation models in the case of schizophrenia. Schizophrenia is a complex disease with considerable variation in the course of disease between individual patients. The three modelling techniques are compared in terms of their ability to deal with this patient heterogeneity, building time, data requirements, medico-scientific experience, simulation time, clinical representation, the timing…
State-Transition | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2014Cost-Effectiveness of Second-Generation Antipsychotics for the Treatment of Schizophrenia
This article, published in Value in Health, describes a Markov model that compares the cost-effectiveness …
This article, published in Value in Health, describes a Markov model that compares the cost-effectiveness of alternate sequences of treatment strategies using second-generation antipsychotics (SGAs) for patients with schizophrenia. First-line treatments include one of the four SGAs: olanzapine (OLZ), risperidone (RSP), quetiapine (QTP), and ziprasidone (ZSD). Patients are able switch to another of these antipsychotics as second-line therapy, and only clozapine (CLZ) is allowed as third-line treatment. Model input parameters were obtained from the Clinical…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ArticlePublication 2015Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder
This article, published in PLoS One, presents a decision tree model followed by a two-state …
This article, published in PLoS One, presents a decision tree model followed by a two-state Markov model that evaluates 28 psychological and pharmacological interventions for social anxiety disorder. The pharmacological interventions include seven selective serotonin/serotonin-noradrenergic reuptake inhibitors, two monoamine oxidase inhibitors (including phenelzine), one anticonvulsant, one noradrenergic and specific serotonergic antidepressant. The psychological interventions include self-help without therapist support (book- and computer-based), self-help with therapist support (book- and computer-based), exposure in vivo, mindfulness training, two…
State-Transition | Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2010Cost-Effectiveness of Psychotherapy for Cluster B Personality Disorders
This article, published in the British Journal of Psychiatry, presents a probabilistic Markov cohort model …
This article, published in the British Journal of Psychiatry, presents a probabilistic Markov cohort model that compares the cost-effectiveness of three treatment strategies (outpatient, day-hospital and inpatient psychotherapy) for patients with cluster B personality disorders. Patient-level data is used to populate the model and the analyses are conducted from the societal and payer perspectives. From the societal perspective, the findings show that the incremental cost-effectiveness ratio (ICER) of day hospital psychotherapy compared to outpatient psychotherapy…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2011Cost-Effectiveness of Psychotherapy for Cluster C Personality Disorders
This article, published in the Journal of Clinical Psychiatry, describes a probabilistic Markov cohort model …
This article, published in the Journal of Clinical Psychiatry, describes a probabilistic Markov cohort model that compares the cost-effectiveness of five treatment modalities (long-term outpatient psychotherapy, short-term and long-term day hospital psychotherapy, and short-term and long-term inpatient psychotherapy) for patients with cluster C personality disorders. The analyses are conducted from the societal and payer perspectives. Patient-level data comes from 466 patients with cluster C personality disorders who were admitted to 6 specialist centers of psychotherapy…
State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe
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