Resources Repository
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ReviewPublication 2016Decision Support for Infectious Disease Control
This report from RAND reviews decision-support tools, including models and nonmodeling approaches, that are relevant to …
This report from RAND reviews decision-support tools, including models and nonmodeling approaches, that are relevant to infectious disease prevention, detection, and response and aligns these tools with real-world policy questions that the tools can help address. This overview is designed to help modelers and other technical experts understand the questions that policymakers will raise and the decisions they must make. The report also presents policymakers with the capabilities and limitations of the different tools that may…
Microsimulation | Health/Medicine | Mathematical Models | Military/Defense | State-Transition | Dynamic Transmission | Dynamic Simulation | Infectious Diseases | Global Governance | Government/Law | Global -
ReviewPublication 2015Agent-Based Models and Microsimulation
This article reviews the principles and applications of agent-based models (ABMs). ABMs are computational models …
This article reviews the principles and applications of agent-based models (ABMs). ABMs are computational models used to simulate the actions and interactions of “agents” within a system. Usually, each agent has a set of rules for how he or she responds to the environment and to other agents. These models are used to gain insight into the emergent behavior of complex systems with many agents, in which the emergent behavior depends upon the micro-level behavior…
Microsimulation | Health/Medicine | Mathematical Models | Military/Defense | State-Transition | Dynamic Simulation | Energy/Engineering | Science/Technology -
ArticlePublication 2023Simulation-Based Comparative Effectiveness Analysis of Policies to Improve Global Maternal Health Outcomes
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) …
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) to less than 70 maternal deaths per 100,000 live births by 2030, with no individual country exceeding 140. However, on current trends the goals are unlikely to be met. The authors used an empirically calibrated Global Maternal Health microsimulation model, which simulates individual women in 200 countries and territories to evaluate the impact of different interventions and strategies from 2022…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | Health Outcomes | Maternal/Reproductive Health | Health Systems | Clinical Care | Global -
Resource PackWeb Portal, Teaching Resource 2023Resource Pack: Maternal Health Models and CEA
This resource pack, curated by the Center for Health Decision Science, provides selected examples of …
This resource pack, curated by the Center for Health Decision Science, provides selected examples of modeling approaches used to conduct analyses relevant to maternal and reproductive health. Some papers focus on a particular problem (e.g., screening for prenatal syphilis, comparison of alternative strategies for safe abortion), while others explore strategies for reducing morbidity and mortality from the entire spectrum of pregnancy and childbirth-related complications. Several of the examples model the primary drivers of maternal mortality (e.g.,…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | Costing Methods | Evidence Synthesis | Cost-Effectiveness Analysis | Maternal/Reproductive Health | Health Systems | Clinical Care | Science/Technology | Global | Sub-Saharan Africa | Middle East & North Africa | Latin America & Caribbean | Asia & Pacific -
ArticlePublication 2020Expanding Oral Disease Treatment is Cost Effective
This study developed a stochastic microsimulation model of oral health conditions, type-2 diabetes (T2D), T2D-related …
This study developed a stochastic microsimulation model of oral health conditions, type-2 diabetes (T2D), T2D-related microvascular diseases, and CVD, to project the cost-effectiveness of expanding periodontal treatment coverage among patients with T2D and periodontitis. Previous randomized trials found that treating periodontitis improved glycemic control in patients with type 2 diabetes (T2D), thus lowering the risks of developing T2D-related microvascular diseases and cardiovascular disease (CVD). The micro-simulation model parameters were obtained from the nationally representative National…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | Cost-Effectiveness Analysis | Chronic Disease/Risk | North America | Graduate -
Resource PackWeb Portal, Teaching Resource 2018Resource Pack: Cervical Cancer Models
This resource pack, curated by the Center for Health Decision Science, is a collection of …
This resource pack, curated by the Center for Health Decision Science, is a collection of models of HPV-related cervical cancer, differing in design, structure and features based on analytic objectives. In many ways, HPV and its related diseases represent a prototypical public health problem given the communicable and non-communicable nature of disease, opportunities for intervention along the entire disease spectrum (e.g., primary and secondary prevention, diagnosis, treatment), the varied ages at which interventions are targeted…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | State-Transition | Dynamic Transmission | Dynamic Simulation | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Health Systems | Clinical Care | Business/Industry | Economics/Finance | Science/Technology | Global -
Resource PackPublication, Teaching Resource 2018Resource Pack: Model Calibration and Validation
This resource pack, curated by the Center for Health Decision Science, provides broad exposure to …
This resource pack, curated by the Center for Health Decision Science, provides broad exposure to empirical calibration and validation methods for mathematical models used in health decision analysis. Included are a selection of overviews, guidelines, tutorials, and applications. Given the complexity of diseases and variation in data quality, there are invariably a number of parameters that are unobserved or cannot be estimated directly but can be inferred through the process of model calibration. Model calibration…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | State-Transition | Dynamic Transmission | Dynamic Simulation -
ArticlePublication 2015Population Health Model (POHEM): An Overview
This paper provides an overview of the rationale, methodology and applications of the Population Health …
This paper provides an overview of the rationale, methodology and applications of the Population Health Model (POHEM). POHEM is a health microsimulation model, developed at Statistics Canada in the early 1990s. The authors describe that POHEM draws together rich multivariate data from a wide range of sources to simulate the lifecycle of the Canadian population, specifically focusing on aspects of health. The model dynamically simulates individuals’ disease states, risk factors, and health determinants, in order…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | Costing Methods | Evidence Synthesis | Chronic Disease/Risk | Health Systems | Policy/Regulation | Clinical Care | Economics/Finance | North America -
GuidelinesPublication 2012Modeling Good Research Practices - Overview: A Report of the ISPOR-SMDM Modeling Task Force-1
This paper provides an overview of the work of the joint Task Force between the …
This paper provides an overview of the work of the joint Task Force between the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the Society for Medical Decision Making (SMDM), provides the overarching recommendations, and discusses future work that is needed. The audience for these papers includes anyone who build models, stakeholders who utilize their results, and those concerned with the use of models to support decision making. This article is part 1 of…
Calibration/Validation | Microsimulation | Health/Medicine | Mathematical Models | Costing Methods | Health Outcomes | Value of Information | State-Transition | Dynamic Transmission | Dynamic Simulation | Decision Analysis | Infectious Diseases