Resources Repository
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ArticlePublication 2007Multiparameter Calibration of a Natural History Model of Cervical Cancer
This paper presents a two-step approach to model calibration of a comprehensive natural history model …
This paper presents a two-step approach to model calibration of a comprehensive natural history model of human papillomavirus (HPV) and cervical cancer. Using primary epidemiologic data from a longitudinal study of women in Brazil, a plausible range for each input parameter was identified that would produce model output within the 95% confidence intervals of the data. The authors then performed a simultaneous search over all input parameters to identify parameter sets that produced output consistent…
Microsimulation | Calibration/Validation | Health/Medicine | Mathematical Models | Infectious Diseases | Chronic Disease/Risk | Latin America & Caribbean -
ArticlePublication 2024Adopting Electric School Buses in the U.S.: Health & Climate Benefits
This article evaluates the health and climate benefits of replacing diesel school buses with electric …
This article evaluates the health and climate benefits of replacing diesel school buses with electric models in the U.S. Despite the high cost of electric buses, their benefits in reducing mortality and childhood asthma, as well as greenhouse gas emissions, could justify the investment. The study quantifies the benefits of replacing an average diesel bus with an electric bus, estimating $84,200 in total benefits per bus, with $40,400 from climate benefits and $43,800 from health…
Benefit-Cost Analysis | Health/Medicine | Environmental Health | Government/Law | North America -
ArticlePublication 2024Hepatitis C Elimination in Rwanda: Progress, Feasibility, Economic Evaluation
This study evaluates the impact of Rwanda's national program launched in 2018 to eliminate hepatitis …
This study evaluates the impact of Rwanda's national program launched in 2018 to eliminate hepatitis C virus (HCV) and identifies strategies to achieve World Health Organization (WHO) elimination goals by 2030. Employing a microsimulation model spanning 2015 to 2050, the analysis assesses HCV epidemic trends, prevalence, mortality, and total care costs under various scenarios. Results show that between 2018 and 2022, over 7 million people were screened and 60,000 treated, projecting Rwanda's potential achievement of…
Microsimulation | Health/Medicine | Infectious Diseases | Chronic Disease/Risk | Sub-Saharan Africa -
ArticlePublication 2023Catalogues of EQ-5D-3L Health-Related Quality of Life Scores for 199 Chronic Conditions and Health Risks for Use in the UK & the U.S.
This study aimed to create UK and US EQ-5D-3L-based health-related quality of life (HRQoL) utility …
This study aimed to create UK and US EQ-5D-3L-based health-related quality of life (HRQoL) utility population catalogues for 199 chronic conditions using ICD-10 codes and health risks. It also sought to develop regression models to predict these utilities in other populations. Methods involved applying UK and US EQ-5D-3L value sets to responses from a Danish dataset, which combined national health survey data with national registers containing patient information on diagnoses, healthcare activities, and socio-demographics. Adjusted…
Preferences/Values | Health/Medicine | Health Outcomes | North America | Europe -
ArticlePublication 2023Alternative Measure of Health for Value Assessment: Equal Value Life-Year
This study examines the equal value life-year (evLY) as an alternative or complementary measure to …
This study examines the equal value life-year (evLY) as an alternative or complementary measure to the quality-adjusted life-year (QALY) in cost-effectiveness analyses. The QALY is criticized for undervaluing treatments that extend the life of individuals with chronic disabilities. The evLY addresses this by assigning equal value to life-years, regardless of health status. Methods included presenting the conceptual rationale for the evLY, explaining its estimation, and comparing results from evLY-based analyses to QALY-based analyses. The study…
Preferences/Values | Health/Medicine | Health Outcomes | Cost-Effectiveness Analysis -
ArticlePublication 2023Designing Guidelines for Those Who Do Not Follow Them: Impact of Adherence Assumptions on Optimal Screening Guidelines
This study examines the impact of real-world screening adherence on the cost-effectiveness of cervical cancer …
This study examines the impact of real-world screening adherence on the cost-effectiveness of cervical cancer screening guidelines. Using a microsimulation model of cervical carcinogenesis, the researchers projected long-term health and economic outcomes for 18 screening algorithms under various adherence scenarios. These included perfect adherence, eight high- and low-coverage "random-complier" scenarios, and three "systematic-complier" scenarios reflecting conditional screening behavior over a lifetime. Results showed that perfect adherence favored the least intensive screening strategy, while any level…
Microsimulation | Health/Medicine | Mathematical Models | Cost-Effectiveness Analysis | Chronic Disease/Risk -
ArticlePublication 2023Cost-Effectiveness and Long-Term Savings of the Bright Bodies Intervention for Childhood Obesity
This study evaluates the cost-effectiveness of Bright Bodies, a family-based pediatric weight management intervention, using …
This study evaluates the cost-effectiveness of Bright Bodies, a family-based pediatric weight management intervention, using a microsimulation model projecting 10-year BMI trajectories of children with obesity. Data from a randomized controlled trial and follow-up study inform the model, which estimates the intervention's effect on BMI reduction and incremental costs compared to clinical control. Results indicate that Bright Bodies reduces BMI by 1.67 kg/m2 per year over 10 years, with an incremental cost of $360 per…
Microsimulation | Health/Medicine | Cost-Effectiveness Analysis | Child/Nutrition | North America -
ArticlePublication 2023New Type 2 Diabetes Microsimulation Model to Estimate Long-Term Health Outcomes, Costs, Cost-Effectiveness
This study presents a microsimulation model designed to estimate the health effects, costs, and cost-effectiveness …
This study presents a microsimulation model designed to estimate the health effects, costs, and cost-effectiveness of interventions for type 2 diabetes in the United States. Unlike existing models that rely on UK data, this model incorporates newly derived risk equations based on US studies, enhancing its applicability to the US context. The model features a highly modular architecture allowing for easy addition of new modules and interventions, facilitating policy decision-making. Internal validation showed good performance,…
Microsimulation | Health/Medicine | Cost-Effectiveness Analysis | Chronic Disease/Risk | North America -
ArticlePublication 2023Evaluation of Diversity of Clinical Trials Informing Health Technology Assessments in the United States: A 5-Year Analysis of Institute for Clinical and Economic Review Assessments
The study assessed the diversity of clinical trials informing assessments by the Institute for Clinical …
The study assessed the diversity of clinical trials informing assessments by the Institute for Clinical and Economic Review (ICER) over five years (2017-2021). It conducted a cross-sectional analysis of 208 pivotal trials across 31 conditions. Findings revealed inadequate representation of racial/ethnic minorities and older adults, with Blacks/African Americans, American Indians/Alaska Natives, and Hispanics/Latinos being notably underrepresented. Whites, Asians, and Native Hawaiian/Other Pacific Islanders were adequately represented. US-based trials better represented Blacks/African Americans and Hispanics/Latinos but…
Technology Assessment | Health/Medicine | Evidence Synthesis | North America