Resources Repository
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ReviewPublication 2023Systematic Literature Review of Gaps and Challenges in Value Assessment of Biosimilars: ISPOR Special Interest Group Report
This study addresses the gaps and challenges in the value assessment of biosimilars and proposes …
This study addresses the gaps and challenges in the value assessment of biosimilars and proposes potential approaches to mitigate them. A multidisciplinary team of biosimilar experts conducted a systematic review of literature and engaged in review rounds to identify these challenges. The article suggests that health technology assessment agencies should accept the comparability exercise approved by regulatory authorities and conduct price comparisons for biosimilars reimbursed for the same indication as the reference biologic. In cases…
Evidence Synthesis | Technology Assessment | Preferences/Values | Policy/Regulation | Health/Medicine -
ArticlePublication 2023Evaluation of Diversity of Clinical Trials Informing Health Technology Assessments in the United States: A 5-Year Analysis of Institute for Clinical and Economic Review Assessments
The study assessed the diversity of clinical trials informing assessments by the Institute for Clinical …
The study assessed the diversity of clinical trials informing assessments by the Institute for Clinical and Economic Review (ICER) over five years (2017-2021). It conducted a cross-sectional analysis of 208 pivotal trials across 31 conditions. Findings revealed inadequate representation of racial/ethnic minorities and older adults, with Blacks/African Americans, American Indians/Alaska Natives, and Hispanics/Latinos being notably underrepresented. Whites, Asians, and Native Hawaiian/Other Pacific Islanders were adequately represented. US-based trials better represented Blacks/African Americans and Hispanics/Latinos but…
Evidence Synthesis | Technology Assessment | Health/Medicine | North America -
ArticlePublication 2023Estimating the US Baseline Distribution of Health Inequalities Across Race, Ethnicity, Geography for Equity-Informative CEA
This study addresses disparities in health outcomes among racial and ethnic groups in the United …
This study addresses disparities in health outcomes among racial and ethnic groups in the United States using Bayesian models to handle suppressed mortality data. By linking multiple US data sets, it demonstrates significant variations in life expectancy, disability-free life expectancy, and quality-adjusted life expectancy based on race, ethnicity, and geographic location. Results show that disparities persist and widen with age, especially between the best-off and worst-off subgroups in socially vulnerable counties. Life expectancy, disability-free life…
Cost-Effectiveness Analysis | Health Outcomes | Social Determinants | Health/Medicine | North America -
ArticlePublication 2023Consolidated Health Economic Evaluation Reporting Standards - Value of Information (CHEERS-VOI): Explanation and Elaboration
The Consolidated Health Economic Evaluation Reporting Standards Value of Information (CHEERS-VOI) 2022 checklist aims to …
The Consolidated Health Economic Evaluation Reporting Standards Value of Information (CHEERS-VOI) 2022 checklist aims to standardize reporting of Value of Information (VOI) analyses conducted alongside economic evaluations, ensuring transparent, reproducible, and high-quality reporting. Developed through a Delphi study, the CHEERS-VOI checklist includes 33 items, with 7 modifications and 6 new reporting criteria, building upon the existing CHEERS statement. Delphi participants rated candidate items through three survey rounds, resulting in the final checklist. This checklist should…
Evidence Synthesis | Value of Information | Health/Medicine -
ArticlePublication 2023Simulation-Based Estimates and Projections of Global, Regional and Country-Level Maternal Mortality by Cause, 1990-2050
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given …
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given the many causes and frequent underreporting of maternal deaths. The authors developed a structural microsimulation model of Global Maternal Health (GMatH) for 200 countries and territories using demographic, epidemiologic, clinical and health system data synthesized from the medical literature, Civil Registration Vital Statistics systems and Demographic and Health Survey data. The model was calibrated to empirical data from 1990 to…
Evidence Synthesis | Health Outcomes | Microsimulation | Calibration/Validation | Maternal/Reproductive Health | Health Systems | Clinical Care | Health/Medicine | Global -
ArticlePublication 2010Alternative Strategies to Reduce Maternal Mortality in India: A Cost-Effectiveness Analysis
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy …
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy and childbirth safety in India. Country- and region-specific data were synthesized using a computer-based model that simulates the natural history of pregnancy and pregnancy-associated complications in individual women, and considers delivery location, attendant, and facility level. Model validation compared projected maternal indicators with empiric data. Strategies consisted of improving coverage of effective interventions that could be provided individually or packaged…
Evidence Synthesis | Cost-Effectiveness Analysis | Mathematical Models | Microsimulation | Maternal/Reproductive Health | Economics/Finance | Health/Medicine | Global | Asia & Pacific -
ArticlePublication 2022Estimated Transmission Outcomes and Costs of SARS-CoV-2 Diagnostic Testing, Screening, and Surveillance Strategies Among a Simulated Population of Primary School Students
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 …
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 billion in March 2021 for testing in schools. The study aimed to analyze the costs and benefits of different COVID-19 testing strategies, particularly focusing on full-time, in-person elementary and middle school education. Utilizing an updated agent-based network model, the study simulated transmission scenarios in schools, considering various testing strategies ranging from diagnostic testing (test-to-stay) to reduce symptom-based isolations, routine screening…
Test Performance | Cost-Effectiveness Analysis | Mathematical Models | Infectious Diseases | Clinical Care | Health/Medicine | Science/Technology | North America -
ArticlePublication 2021Racial and Ethnic Inequities in the Early Distribution of U.S. COVID-19 Testing Sites and Mortality
In 2020, U.S. COVID-19 testing sites were pivotal not just for diagnosis but also to …
In 2020, U.S. COVID-19 testing sites were pivotal not just for diagnosis but also to provide data that would contribute to understanding transmission. This research explored how these sites were distributed in relation to racial and ethnic demographics and its connection to observed disparities in COVID-19 outcomes. Data from mid-April to late May 2020 revealed that testing sites were not equally distributed among racial groups. Specifically, there was an overrepresentation of testing sites in areas…
Test Performance | Health Outcomes | Infectious Diseases | Social Determinants | Policy/Regulation | Culture/Society | Health/Medicine | Science/Technology | North America -
ArticlePublication 2023Valuing Mortality Risk: Per Life, Life Year, or QALY?
It is important to consider age and other relevant factors when assessing the value associated …
It is important to consider age and other relevant factors when assessing the value associated with reducing risks to ensure a comprehensive and accurate understanding of its impact. In a recent paper, it is explained that the value of risk reduction, whether it is a temporary or persistent reduction, can be defined using the "value per statistical life" (VSL), "value per statistical life year" (VSLY), or "value per quality-adjusted life year" (VQALY).
Cost-Effectiveness Analysis | Risk Analysis | Preferences/Values | Benefit-Cost Analysis