Resources Repository
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ArticlePublication 2008Mathematical Models of Cervical Cancer Prevention in the Asia Pacific Region
This article reports on a model-based approach to estimate averted cervical cancer cases and deaths, …
This article reports on a model-based approach to estimate averted cervical cancer cases and deaths, disability-adjusted life years (DALYs) and incremental cost-effectiveness ratios (I$/DALY averted) for vaccination of young adolescent girls against human papillomavirus (HPV) types 16 and 18. The authors used population-based and epidemiologic data for 25 countries in Asia (22 GAVI-Alliance eligible countries, Thailand, China and Japan). They found that an absolute reduction in lifetime cancer risk varied across countries, depending on incidence,…
Cost-Effectiveness Analysis | Calibration/Validation | Health/Medicine | Asia & Pacific | Mathematical Models | Microsimulation | Infectious Diseases | Chronic Disease/Risk | Health Systems | Economics/Finance | Science/Technology -
ArticlePublication 2008Health and Economic Impact of HPV 16 and 18 Vaccination and Cervical Cancer Screening in India
As cervical cancer is a leading cause of cancer death among women in low-income countries, …
As cervical cancer is a leading cause of cancer death among women in low-income countries, with approximately 25% of cases worldwide occurring in India, these authors estimated the potential health and economic impact of different cervical cancer prevention strategies in India. After empirically calibrating a cervical cancer model to country-specific epidemiologic data, they projected cancer incidence, life expectancy, and lifetime costs (I$2005), and calculated incremental cost-effectiveness ratios (I$/YLS) for the following strategies: pre-adolescent vaccination of…
Cost-Effectiveness Analysis | Calibration/Validation | Health/Medicine | Asia & Pacific | Microsimulation | Infectious Diseases | Chronic Disease/Risk | Health Systems | Clinical Care | Economics/Finance | Science/Technology -
ArticlePublication 2023Catalogues of EQ-5D-3L Health-Related Quality of Life Scores for 199 Chronic Conditions and Health Risks for Use in the UK & the U.S.
This study aimed to create UK and US EQ-5D-3L-based health-related quality of life (HRQoL) utility …
This study aimed to create UK and US EQ-5D-3L-based health-related quality of life (HRQoL) utility population catalogues for 199 chronic conditions using ICD-10 codes and health risks. It also sought to develop regression models to predict these utilities in other populations. Methods involved applying UK and US EQ-5D-3L value sets to responses from a Danish dataset, which combined national health survey data with national registers containing patient information on diagnoses, healthcare activities, and socio-demographics. Adjusted…
Health Outcomes | Health/Medicine | Europe | Preferences/Values | North America -
BriefPublication 2023Dynamic Mortality Modeling: Incorporating Predictions of Future General Population Mortality into CEA
This study addresses the limitations of conventional static approaches in health economic modeling by proposing …
This study addresses the limitations of conventional static approaches in health economic modeling by proposing a dynamic general population mortality modeling method. Using a replication of the axicabtagene ciloleucel model from NICE appraisal TA559, the authors demonstrate the potential impact of this approach on estimating life-years and cost-effectiveness. The model utilizes national mortality projections and updates mortality rates annually, considering different assumptions around age distribution. Results show that incorporating dynamic calculations increases undiscounted life-years attributed…
Cost-Effectiveness Analysis | Health/Medicine | Europe | Mathematical Models -
Tutorial/PrimerPublication, Teaching Resource 2023Survival Extrapolation Incorporating General Population Mortality Using Excess Hazard and Cure Models: Tutorial
The study examines the utility of excess hazard (EH) methods in reducing model uncertainty when …
The study examines the utility of excess hazard (EH) methods in reducing model uncertainty when estimating long-term survival in cost-effectiveness analyses. Using a case study of breast cancer patients, standard parametric survival models were compared with EH methods incorporating general population mortality rates, with and without a cure parameter. Results showed substantial variability in survival extrapolations across standard models, while EH methods, particularly EH cure models, significantly reduced uncertainty. Long-term treatment effects approached null for…
Cost-Effectiveness Analysis | Health/Medicine | Europe | Mathematical Models | Chronic Disease/Risk -
ArticlePublication 2022Comparing Health Gains, Costs & Cost-Effectiveness of Interventions in Australia & New Zealand
This paper synthesizes the health gains, costs, and cost-effectiveness of health interventions in Australia and New …
This paper synthesizes the health gains, costs, and cost-effectiveness of health interventions in Australia and New Zealand (NZ) from studies conducted with comparable methods, and reports results in the form of an online interactive league table. Studies from the Australia Cost-Effectiveness research and NZ Burden of Disease Epidemiology, Equity and Cost-Effectiveness Programmes and studies were included which reported health-adjusted life years (HALYs) and net health system costs and/or incremental cost-effectiveness ratios, used a time horizon of…
Cost-Effectiveness Analysis | Health/Medicine | Asia & Pacific | Priority Setting/Ethics | Infectious Diseases | Chronic Disease/Risk | Mental Health | Health Systems | Oceania -
ArticlePublication 2020Impact of Cigarette Tax Increase in India
This article, published in Gates Open Research, examines the impact of a one-time large cigarette …
This article, published in Gates Open Research, examines the impact of a one-time large cigarette price increase, through an increase in excise tax, on health and financing outcomes in four Indian states. Extended cost-effectiveness analysis (ECEA) is used to estimate, across income quintiles, the life-years gained, treatment cost averted, number of men avoiding catastrophic health expenditures and extreme poverty, and additional tax revenue collected with a cigarette price increase to Indian Rupees (INR) 10 plus…
Cost-Effectiveness Analysis | Health/Medicine | Asia & Pacific | Chronic Disease/Risk | Health Systems | Policy/Regulation -
ArticlePublication 2020Who Benefits Most from Extending Financial Protection for Cataract Surgery in Vietnam?: An ECEA
This study evaluated the potential impact, on health and financial protection, of eliminating medical and …
This study evaluated the potential impact, on health and financial protection, of eliminating medical and non-medical out-of-pocket costs associated with cataract surgery in Vietnam using extended cost-effectiveness analysis.
Cost-Effectiveness Analysis | Health/Medicine | Asia & Pacific | Priority Setting/Ethics | Chronic Disease/Risk | Social Determinants | Health Systems -
ArticlePublication 2017Distributional Benefits of Tobacco Tax and Smoke-Free Workplaces in China
This study used the extended cost–effectiveness analysis (ECEA) to evaluate, across income quintiles of the …
This study used the extended cost–effectiveness analysis (ECEA) to evaluate, across income quintiles of the male population, the premature deaths averted, the change in tax revenues generated, and the financial risk protection procured, that would follow a 75% increase in cigarette prices through substantial increments in excise tax fully passed onto consumers, and a nationwide total implementation of workplace smoking bans. A 75% increase in cigarette prices would avert about 24 million premature deaths among…
Cost-Effectiveness Analysis | Health/Medicine | Asia & Pacific | Priority Setting/Ethics | Mathematical Models | Chronic Disease/Risk | Social Determinants | Policy/Regulation