Resources Repository
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ArticlePublication 2008Health and Economic Impact of HPV 16 and 18 Vaccination and Cervical Cancer Screening in India
As cervical cancer is a leading cause of cancer death among women in low-income countries, …
As cervical cancer is a leading cause of cancer death among women in low-income countries, with approximately 25% of cases worldwide occurring in India, these authors estimated the potential health and economic impact of different cervical cancer prevention strategies in India. After empirically calibrating a cervical cancer model to country-specific epidemiologic data, they projected cancer incidence, life expectancy, and lifetime costs (I$2005), and calculated incremental cost-effectiveness ratios (I$/YLS) for the following strategies: pre-adolescent vaccination of…
Microsimulation | Calibration/Validation | Clinical Care | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Health Systems | Economics/Finance | Health/Medicine | Science/Technology | Asia & Pacific -
ArticlePublication 2007Including Boys in an HPV Vaccination Program: A CEA in a Low-Resource Setting
This paper looks at the cost-effectiveness of including boys vs girls alone in a pre-adolescent vaccination …
This paper looks at the cost-effectiveness of including boys vs girls alone in a pre-adolescent vaccination program against human papillomavirus (HPV) types 16 and 18 in Brazil. Using demographic, epidemiological, and cancer data from Brazil, the authors developed a dynamic transmission model of HPV infection between males and females. Model-projected reductions in HPV incidence under different vaccination scenarios were applied to a stochastic model of cervical carcinogenesis to project lifetime costs and benefits. They found that at 90%…
Microsimulation | Calibration/Validation | Clinical Care | Cost-Effectiveness Analysis | Infectious Diseases | Chronic Disease/Risk | Health/Medicine | Latin America & Caribbean -
ArticlePublication 2007Modeling HPV and Cervical Cancer in the U.S. for Analyses of Screening and Vaccination
This paper discusses a model of human papillomavirus (HPV) and cervical cancer that incorporates uncertainty …
This paper discusses a model of human papillomavirus (HPV) and cervical cancer that incorporates uncertainty about the natural history of disease that was used to provide quantitative insight into U.S. policy choices for cervical cancer prevention. The authors developed a stochastic microsimulation of cervical cancer that distinguishes different HPV types by their incidence, clearance, persistence, and progression. For each set of sampled input parameters, likelihood-based goodness-of-fit (GOF) scores were computed based on comparisons between model-predicted…
Microsimulation | Calibration/Validation | Clinical Care | Infectious Diseases | Chronic Disease/Risk | Health/Medicine | Science/Technology | North America -
ExerciseNone, Teaching Resource 2024Lab: Autoimmune Encephalitis Decision Tree Model
This tutorial walks through the development of a decision tree model based on a published …
This tutorial walks through the development of a decision tree model based on a published cost-effectiveness analysis of routine screening for autoimmune encephalitis in patients with first-episode psychosis in the United States based on the published article: Ross EL, Becker JE, Linnoila JJ, Soeteman DI. Cost-Effectiveness of Routine Screening for Autoimmune Encephalitis in Patients with First-Episode Psychosis in the United States. J Clin Psychiatry 2020; 82 (1): 19m13168. The tutorial describes how to build the…
Decision Analysis | Clinical Care | Mathematical Models | Cost-Effectiveness Analysis | Health/Medicine | Graduate | Doctoral | Professional -
Tutorial/PrimerPublication, Teaching Resource 2024Tutorial: Building Decision Trees
This tutorial illustrates the basic steps needed to develop decision trees in Amua using a …
This tutorial illustrates the basic steps needed to develop decision trees in Amua using a disease screening example. It details the process of how to build the structure of a decision tree, parameterize the model with probabilities and relevant outcomes (i.e., life expectancy), evaluate three alternative screening strategies in a baseline scenario, and perform one-way sensitivity analyses to assess the robustness of the results to different parameter values. Amua, the Swahili word meaning “decide”/“solve”, is…
Decision Analysis | Clinical Care | Probability/Bayes | Mathematical Models | Health/Medicine | Graduate | Doctoral | Professional -
Resource PackWeb Portal, Teaching Resource 2023Resource Pack: Cost-Effectiveness of Screening and Treatment for Hypertension
Hypertension is a relevant example for teaching clinical decision making, diagnostic test performance, positivity criterion, …
Hypertension is a relevant example for teaching clinical decision making, diagnostic test performance, positivity criterion, and cost-effectiveness analysis. This resource pack provides examples of decision analyses and cost-effectiveness analyses for the management and treatment of hypertension, with a predominant focus on the U.S. Analyses are included that predate the 2017 American College of Cardiology/American Heart Association Clinical Practice Guidelines, along with more recent examples that followed release of the guidelines. Resources are also included that…
Decision Analysis | Clinical Care | Preferences/Values | Test Performance | Cost-Effectiveness Analysis | Chronic Disease/Risk | Economics/Finance | Health/Medicine | Science/Technology | North America | Europe | Graduate | Doctoral | Professional | Critical Thinking/Analysis | Policy Translation | Quantitative Literacy -
ExerciseNone, Teaching Resource 2024Lab: Giant Cell Arteritis Decision Tree Model
This tutorial walks through the development of a decision tree model focused on Giant Cell …
This tutorial walks through the development of a decision tree model focused on Giant Cell Arteritis. It describes how to build the model structure, assign probabilities and outcomes based on imperfect test characteristics and epidemiologic estimates, evaluate alternative treatment strategies, and conduct one-way sensitivity analyses to assess which model parameters may impact the optimal treatment choice. Amua, the Swahili word meaning “decide”/“solve”, is an open source modeling framework and probabilistic programming language for decision analysis…
Decision Analysis | Clinical Care | Probability/Bayes | Mathematical Models | Health/Medicine | Graduate | Doctoral | Professional -
ArticlePublication 2013Modeling the Effectiveness of Initial Management Strategies for Ductal Carcinoma in Situ
This paper compares alternative strategies to manage ductal carcinoma in situ (DCIS). The authors used …
This paper compares alternative strategies to manage ductal carcinoma in situ (DCIS). The authors used a disease simulation model to simulate the clinical events after six treatments (lumpectomy alone, lumpectomy with radiation, lumpectomy with radiation and tamoxifen, lumpectomy with tamoxifen, and mastectomy with and without breast reconstruction). Outcomes included disease-free, invasive disease-free, overall survival and breast preservation. Data were from the published literature. The results showed that for women aged 45 years at diagnosis, both mastectomy…
Decision Analysis | Clinical Care | Health Outcomes | Health/Medicine -
Tutorial/PrimerPublication, Teaching Resource 2024Tutorial: CEA of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals
This self-directed tutorial is about a decision analytic model of Alternative Colorectal Cancer Screening Strategies …
This self-directed tutorial is about a decision analytic model of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals. This tutorial is based on the publication: Benamouzig R, Barré S, Saurin J-C et al. Cost-Effectiveness Analysis of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals. Therapeutic Advances in Gastroenterology 2021; 14. About the Alan Colowick Innovation Fund The case-based tutorials in this teaching pack were created with support from the CHDS Alan Colowick Innovation Fund, established with…
Decision Analysis | Clinical Care | Mathematical Models | Health/Medicine | Graduate | Doctoral | Professional