Resources Repository
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ArticlePublication 2020Incorporating Perspective into Clinical Decisions
Part of a six-part series of articles on clinical decision making, in this article, the …
Part of a six-part series of articles on clinical decision making, in this article, the authors discuss how to incorporate perspective into clinical decisions, explicitly acknowledging that the treating physician is not the only stakeholder in these decisions. The authors use 2 case studies to demonstrate how changes in perspective can alter the clinical decision as well lead to both intended and unintended consequences to the outcomes.
Health/Medicine | Clinical Care | Preferences/Values | Priority Setting/Ethics | Health Outcomes | Health Systems -
Teaching PackPublication, Teaching Resource 2022Teaching Pack: Population Health Outcomes
In this teaching pack on Population Health Outcomes, students learn how to describe outcomes at a …
In this teaching pack on Population Health Outcomes, students learn how to describe outcomes at a population level using quality adjusted life years (QALYs), including how to calculate QALYs, the assumptions underlying them, how to derive QALYs using indirect utility measures, and what are some of the ethical criticisms of QALYs. Materials include an instructor’s note, videos, companion slides, a glossary, an annotated bibliography, and sample exercises. Learning Objectives Define Quality-Adjusted Life Years (QALYs)…
Health/Medicine | Injuries/Accidents | Preferences/Values | Priority Setting/Ethics | Health Outcomes | College | Graduate | Doctoral -
ArticlePublication 2023Achieving the Cancer Moonshot Goal
The Cancer Moonshot seeks to reduce age-standardized cancer mortality rates by at least 50% over …
The Cancer Moonshot seeks to reduce age-standardized cancer mortality rates by at least 50% over the next 25 years. This article estimates trends in U.S. cancer mortality for all cancers and the six leading types and reviews opportunities to prevent, detect, and treat these common cancers.
Health/Medicine | Clinical Care | Priority Setting/Ethics | Mathematical Models | Health Systems | North America -
ArticlePublication 2020Testing for SARS-CoV-2 Antibodies
Antibody testing can determine previous exposure to SARS-CoV-2 virus. Recently, the UK government has made …
Antibody testing can determine previous exposure to SARS-CoV-2 virus. Recently, the UK government has made antibody testing available to anyone wanting it, even if there is no clinical indication. The purpose of this article is to provide guidance for when to consider antibody testing in individuals with and without symptoms suggestive of current or past SARS-CoV-2 infection. Key points made by the authors include: (1) antibody testing is likely to be most useful 2 weeks…
Health/Medicine | Clinical Care | Probability/Bayes | Test Performance | Technology Assessment | Infectious Diseases -
ArticlePublication 2020Bayes' Theorem, COVID-19, and Screening Tests
This article reviews the implications of increased testing for COVID-19 using reverse transcriptase polymerase chain …
This article reviews the implications of increased testing for COVID-19 using reverse transcriptase polymerase chain reaction (rRT-PCR) through the application of Bayes’ Theorem for three hypothetical, stylized case scenarios. The scenarios involve three patients with a low, moderate, and high pre-test probability of COVID-19 infection. The category of low probability would include "asymptomatic individuals in a presumed low prevalence environment" and might vary from 10 to 20%. The category of moderate probability would include "individuals…
Health/Medicine | Clinical Care | Probability/Bayes | Test Performance | Infectious Diseases -
ArticlePublication 2020Weighing Evidence to Inform Clinical Decisions
The authors use a clinical example to simulate how treatment discussions can be complicated when new evidence is introduced …
The authors use a clinical example to simulate how treatment discussions can be complicated when new evidence is introduced that conflicts with existing guidelines. Even when evidence is consistent, the authors point out that current guidelines can have interpretations that don't agree with available evidence. They develop a step-wise algorithm to help guide individual clinical decisions even in the absence of general consensus related to appropriate testing and treatment.
Health/Medicine | Clinical Care | Priority Setting/Ethics | Evidence Synthesis -
ArticlePublication 2020Clinical Decision Making: Using a Diagnostic Test
This article is part of a 6-part series on clinical decision making. The authors use …
This article is part of a 6-part series on clinical decision making. The authors use two clinical examples to review the principles of interpreting diagnostic test results. They outline an approach that can be used to determine how to select and apply tests and their results to the practice of internal medicine. Topics covered in the two case studies include sensitivity and specificity, positive predictive and negative predictive value of tests, and how to estimate…
Health/Medicine | Clinical Care | Probability/Bayes | Test Performance -
Teaching PackPublication, Teaching Resource 2022Teaching Pack: Valuing Individual Health Outcomes
In this teaching pack on Valuing Individual Health Outcomes, students learn how to assign quantitative …
In this teaching pack on Valuing Individual Health Outcomes, students learn how to assign quantitative values to health outcomes at the individual level, including: expected utility theory, the axioms of this theory, distinguishing between preference-based measures of value and health-related quality of life outcomes, measuring utility using the standard gamble, the time trade-off, and the visual analog scale, and understanding the limitations of these measures. Materials include an instructor's note, videos, companion slides, a glossary,…
Health/Medicine | Injuries/Accidents | Preferences/Values | Health Outcomes | Decision Analysis | Economics/Finance | College | Graduate | Doctoral -
Resource PackPublication, Teaching Resource 2017Resource Pack: CEA Herpes Zoster Vaccine
This resource pack on the cost-effectiveness of herpes zoster vaccination was curated to support Dr. …
This resource pack on the cost-effectiveness of herpes zoster vaccination was curated to support Dr. Lisa Prosser's seminar on November 9, 2017 at the Center for Health Decision Science. Dr. Prosser discussed an economic evaluation of vaccination against herpes zoster. Herpes zoster—more commonly known as shingles—presents a major burden for older Americans but, until recently, the only available vaccine (Zoster Vaccine Live, ZVL) was relatively ineffective past 10 years. A recently approved vaccine–herpes zoster subunit…
Health/Medicine | Clinical Care | Preferences/Values | Costing Methods | Health Outcomes | Mathematical Models | Cost-Effectiveness Analysis | Infectious Diseases | Culture/Society | Science/Technology | North America | Europe