Resources Repository
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ArticlePublication 2013Modeling the Effectiveness of Initial Management Strategies for Ductal Carcinoma in Situ
This paper compares alternative strategies to manage ductal carcinoma in situ (DCIS). The authors used …
This paper compares alternative strategies to manage ductal carcinoma in situ (DCIS). The authors used a disease simulation model to simulate the clinical events after six treatments (lumpectomy alone, lumpectomy with radiation, lumpectomy with radiation and tamoxifen, lumpectomy with tamoxifen, and mastectomy with and without breast reconstruction). Outcomes included disease-free, invasive disease-free, overall survival and breast preservation. Data were from the published literature. The results showed that for women aged 45 years at diagnosis, both mastectomy…
Decision Analysis | Health/Medicine | Clinical Care | Health Outcomes -
ArticlePublication 2021CEA of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals
Fecal occult blood testing with an immunochemical test (FIT) is generally considered as the most …
Fecal occult blood testing with an immunochemical test (FIT) is generally considered as the most cost-effective alternative in colorectal cancer screening programs for average risk individuals without family history. Colorectal screening guidelines recommend colonoscopy every 3-5 years for high-risk individuals with a family history. The authors use a microsimulation model of the natural history of colorectal cancer (CRC) to compare the costs, quality-adjusted life years, and cost effectiveness associated with several screening strategies in high-risk individuals,…
Health/Medicine | Clinical Care | Cost-Effectiveness Analysis -
Tutorial/PrimerPublication, Teaching Resource 2024Tutorial: CEA of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals
This self-directed tutorial is about a decision analytic model of Alternative Colorectal Cancer Screening Strategies …
This self-directed tutorial is about a decision analytic model of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals. This tutorial is based on the publication: Benamouzig R, Barré S, Saurin J-C et al. Cost-Effectiveness Analysis of Alternative Colorectal Cancer Screening Strategies in High-Risk Individuals. Therapeutic Advances in Gastroenterology 2021; 14. About the Alan Colowick Innovation Fund The case-based tutorials in this teaching pack were created with support from the CHDS Alan Colowick Innovation Fund, established with…
Decision Analysis | Health/Medicine | Clinical Care | Mathematical Models | Graduate | Doctoral | Professional -
Tutorial/PrimerPublication, Teaching Resource 2024Tutorial: Introduction to Programming Decision Trees
This self-directed tutorial walks through the development of a decision tree using Amua to evaluate …
This self-directed tutorial walks through the development of a decision tree using Amua to evaluate three initial management strategies for ductal carcinoma in situ (DCIS) based on a published analysis: Soeteman DI, Stout NK, Ozanne EM et al. Modeling the Effectiveness of Initial Management Strategies for Ductal Carcinoma in Situ. J Natl Cancer Inst 2013; 105 (11): 774-781. The tutorial describes how to build the model structure, parameterize the model probabilities and outcomes based on…
Decision Analysis | Health/Medicine | Clinical Care | Mathematical Models | Graduate | Doctoral | Professional -
BriefPublication 2023Simulation Modeling to Guide Priority Setting in Global Maternal Health
This study developed the Global Maternal Health (GMatH) microsimulation model to evaluate maternal health policy …
This study developed the Global Maternal Health (GMatH) microsimulation model to evaluate maternal health policy interventions across 200 countries and territories from 1990 to 2050. It addresses challenges in measuring maternal mortality by simulating individual women's reproductive lifecycles. Various interventions, including family planning and facility-based care, were simulated to compare against a baseline scenario projecting the global maternal mortality ratio (MMR) to decrease to 167 per 100,000 live births by 2030. Results suggest that while…
Health/Medicine | Maternal/Reproductive Health | Microsimulation | Cost-Effectiveness Analysis | Policy/Regulation | Global -
ArticlePublication 2010Alternative Strategies to Reduce Maternal Mortality in India: A Cost-Effectiveness Analysis
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy …
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy and childbirth safety in India. Country- and region-specific data were synthesized using a computer-based model that simulates the natural history of pregnancy and pregnancy-associated complications in individual women, and considers delivery location, attendant, and facility level. Model validation compared projected maternal indicators with empiric data. Strategies consisted of improving coverage of effective interventions that could be provided individually or packaged…
Health/Medicine | Maternal/Reproductive Health | Evidence Synthesis | Mathematical Models | Microsimulation | Cost-Effectiveness Analysis | Economics/Finance | Global | Asia & Pacific -
ArticlePublication 2022Estimated Transmission Outcomes and Costs of SARS-CoV-2 Diagnostic Testing, Screening, and Surveillance Strategies Among a Simulated Population of Primary School Students
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 …
In the wake of the COVID-19 pandemic's significant educational disruptions, the U.S. government allocated $10 billion in March 2021 for testing in schools. The study aimed to analyze the costs and benefits of different COVID-19 testing strategies, particularly focusing on full-time, in-person elementary and middle school education. Utilizing an updated agent-based network model, the study simulated transmission scenarios in schools, considering various testing strategies ranging from diagnostic testing (test-to-stay) to reduce symptom-based isolations, routine screening…
Health/Medicine | Clinical Care | Test Performance | Mathematical Models | Cost-Effectiveness Analysis | Infectious Diseases | Science/Technology | North America -
ArticlePublication 2023Effects of Public Financing of Essential Maternal and Child Health Interventions Across Wealth Quintiles in Nigeria: An Extended Cost-Effectiveness Analysis
This study evaluates the potential health and financial risk protection benefits of public financing for …
This study evaluates the potential health and financial risk protection benefits of public financing for maternal, newborn, and child health (MNCH) interventions in Nigeria, focusing on different wealth quintiles. Employing extended cost-effectiveness analysis, the research assesses the impact of a policy ensuring zero out-of-pocket costs for 18 essential MNCH services. Three scenarios were modeled: status quo, uniform scale-up, and pro-poor scale-up. Findings suggest that a 5% increase in coverage for all quintiles could prevent significant…
Health/Medicine | Maternal/Reproductive Health | Health Outcomes | Mathematical Models | Cost-Effectiveness Analysis | Policy/Regulation | Sub-Saharan Africa -
ArticlePublication 2022Cost-Effectiveness of Masked Hypertension Screening and Treatment
The study assessed the health and economic outcomes of screening and treating masked hypertension in …
The study assessed the health and economic outcomes of screening and treating masked hypertension in U.S. adults using the Cardiovascular Disease (CVD) Policy Model, a microsimulation model. The model simulated 100,000 adults suspected of having masked hypertension (office blood pressure [BP] of 120–129/<80 mm Hg, not on antihypertensive medications, and without a history of CVD). Interventions included: usual care alone, usual care with ambulatory BP monitoring (ABPM), and usual care with home BP monitoring (HBPM).…
Health/Medicine | Clinical Care | Microsimulation | Cost-Effectiveness Analysis | Chronic Disease/Risk | North America