Resources Repository
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ArticlePublication 2019Cost-Effectiveness of Latent TB Screening before Immigration to Low-Incidence Countries
Despite prospective migrants to countries where the incidence of TB is low receiving TB screening …
Despite prospective migrants to countries where the incidence of TB is low receiving TB screening for active infections, screening for latent TB infection before immigration is rare. The authors used discrete event simulation to evaluate the cost-effectiveness preimmigration latent TB infection screening for migrants to low-incidence countries. They calculated cost per quality-adjusted life-year gained for migrants from countries with different TB incidences. Their analysis when combined with research on sustainability, acceptability, and program implementation can…
Dynamic Simulation | Mathematical Models | Infectious Diseases | Cost-Effectiveness Analysis | Government/Law | Health/Medicine | Global -
ArticleWeb Portal 2017PLoS Collection: Prevention, Diagnosis and Treatment of Sexually Transmitted Infections
Globally, the World Health Organization (WHO) estimates that more than one million new sexually transmitted …
Globally, the World Health Organization (WHO) estimates that more than one million new sexually transmitted infections (STIs) occur each day, incurring a very substantial burden of morbidity, mortality and additional infections. The pathogens responsible include bacteria, parasites and viruses, and intensive research is needed to address the substantial barriers to diagnosis and treatment of STIs, and the behavioral challenges of prevention. This PLOS collection, published in collaboration with WHO, focuses on global policy and systems…
Mathematical Models | Dynamic Transmission | Infectious Diseases | Priority Setting/Ethics | Costing Methods | Cost-Effectiveness Analysis | Health Systems | Economics/Finance | Health/Medicine | Sub-Saharan Africa | Middle East & North Africa | Latin America & Caribbean | Asia & Pacific -
ArticlePublication 2017Estimating the Fitness Cost and Benefit of Cefixime Resistance in Neisseria Gonorrhoeae
Gonorrhoea is one of the most common bacterial sexually transmitted infections in England, and more …
Gonorrhoea is one of the most common bacterial sexually transmitted infections in England, and more than half of annual infections occur in men who have sex with men (MSM). As the bacterium has developed resistance to each first-line antibiotic in turn, an improved understanding is needed of fitness benefits and costs of antibiotic resistance to inform control policy and planning. The authors developed a stochastic compartmental model representing the natural history and transmission of cefixime-sensitive…
Risk Analysis | Dynamic Transmission | Infectious Diseases | Decision Analysis | Health Systems | Policy/Regulation | Government/Law | Health/Medicine | Science/Technology | Global -
OrganizationWeb Portal 2024One Health Trust
One Health Trust, formally the Center for Disease Dynamics, Economics & Policy (CDDEP), was founded …
One Health Trust, formally the Center for Disease Dynamics, Economics & Policy (CDDEP), was founded with the objective of using research to support better decision-making in health policy. One Health Trust researchers employ a range of expertise—including economics, epidemiology, disease modeling, risk analysis, and statistics—to conduct actionable, policy-oriented research on malaria, antibiotic resistance, disease control priorities, environmental health, alcohol and tobacco, and other global health priorities. One Health Trust projects are global in scope, spanning…
Mathematical Models | Environmental Health | Infectious Diseases | Costing Methods | Health Outcomes | Cost-Effectiveness Analysis | Technology Assessment | Chronic Disease/Risk | Social Determinants | Policy/Regulation | Climate/Environment | Economics/Finance | Health/Medicine | Global | Sub-Saharan Africa | Asia & Pacific -
ArticlePublication 2016Cost-Effectiveness of Routine Vaccination With a Live-Attenuated Dengue Vaccine: Model Comparison
Large Phase III trials across Asia and Latin America have demonstrated the efficacy of a recombinant, …
Large Phase III trials across Asia and Latin America have demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 months following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. This paper reports predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine…
Mathematical Models | Dynamic Transmission | Infectious Diseases | Cost-Effectiveness Analysis | Child/Nutrition | Health Systems | Global Governance | Climate/Environment | Economics/Finance | Health/Medicine | Latin America & Caribbean | Asia & Pacific -
Tutorial/PrimerPublication, Teaching Resource 2015Economic Evaluations with Agent-Based Modelling: An Introduction
This tutorial presents the basic concepts and important features of agent-based models, and provides a …
This tutorial presents the basic concepts and important features of agent-based models, and provides a case study of a simple cost effectiveness analysis of screening for an infectious disease. Agent-based modelling (ABM) is a relatively new technique, which overcomes some of the limitations of other methods commonly used for economic evaluations. These limitations include linearity, homogeneity and stationarity. Agents in ABMs are autonomous entities, who interact with each other and with the environment. ABMs provide…
Dynamic Simulation | Mathematical Models | Infectious Diseases | Health/Medicine | Graduate | Doctoral | Professional | Conceptual Mapping | Quantitative Literacy -
ArticlePublication 2014Cost-Effectiveness of Female HPV Vaccination in 179 Countries: A PRIME Modelling Study
The authors present a simple generic model, Papillomavirus Rapid Interface for Modelling and Economics (PRIME), …
The authors present a simple generic model, Papillomavirus Rapid Interface for Modelling and Economics (PRIME), used to assess cost-effectiveness and health effects of vaccination of girls against HPV before sexual debut in terms of burden of cervical cancer and mortality. The PRIME models incidence according to proposed vaccine efficacy against HPV 16/18, vaccine coverage, cervical cancer incidence and mortality, and HPV type distribution. It assumes lifelong vaccine protection and no changes to other screening programs…
Mathematical Models | Calibration/Validation | Infectious Diseases | Health Outcomes | Cost-Effectiveness Analysis | Chronic Disease/Risk | Health Systems | Health/Medicine | Global | Sub-Saharan Africa | Middle East & North Africa | Latin America & Caribbean | Asia & Pacific -
Lesson/ModuleWeb Portal, Teaching Resource 2014Life Saving Maths: How Does Vaccination Work?
This learning module explores decision-making in vaccinations, and unpacks how epidemics spread through herd immunity. …
This learning module explores decision-making in vaccinations, and unpacks how epidemics spread through herd immunity. Through video clips, Dr. Julia Gog and Dr. Andrew Conlan explain simple mathematical models for infectious disease to illustrate the importance of immunization. Related resources, such as activities, worksheets, and presentations, are available to help students investigate the effects of vaccination. These activities are recommended to be used together but can also be used independently. They are aimed at a…
Mathematical Models | Dynamic Transmission | Infectious Diseases | Health/Medicine | Science/Technology | Global | High School | Critical Thinking/Analysis | Quantitative Literacy -
Lesson/ModuleWeb Portal, Teaching Resource 2014Maths and Our Health
This learning module provides teaching packs to explore biomedical real-world applications of probability and statistics …
This learning module provides teaching packs to explore biomedical real-world applications of probability and statistics in decision-making. Each pack provides videos and supplemental materials, including presentations, worksheets, and games. Topics include: “Eating Bacon Sandwiches is Bad for You!” Evaluating Risk Epidemics: Modelling with Mathematics Life Saving Maths: How Does Vaccination Work? The Economics of Health: How Do We Decide? The Test is Positive: But What Are the Odds It’s Wrong?
Mathematical Models | Test Performance | Infectious Diseases | Decision Theory | Decision Analysis | Child/Nutrition | Chronic Disease/Risk | Economics/Finance | Health/Medicine | Science/Technology | Global | Middle School | High School | Critical Thinking/Analysis | Decision Making/Leadership | Quantitative Literacy