Resources Repository
-
ArticlePublication 2022Cost-Effectiveness & Value-of-Information Analysis Using Machine Learning-Based Metamodeling: A Case of Hepatitis C Treatment
This study compares machine learning (ML)-based metamodels with conventional metamodeling approaches in replicating the outcomes …
This study compares machine learning (ML)-based metamodels with conventional metamodeling approaches in replicating the outcomes of a complex simulation model of hepatitis C virus (HCV) natural history. Three ML-based metamodels (random forest, support vector regression, and artificial neural networks) and a linear regression-based metamodel were developed from the simulation model's 40 input parameters. Performance evaluation included root mean squared error (RMSE) and Pearson's R2 on normalized data. ML-based metamodels generally outperformed linear regression, with random…
Health/Medicine | Chronic Disease/Risk | Infectious Diseases | Mathematical Models -
ArticlePublication 2021COVID-19, Fake News, and Vaccines: Should Regulation Be Implemented?
This article analyzes issues concerning the establishment of compulsory vaccination against COVID-19, as well as …
This article analyzes issues concerning the establishment of compulsory vaccination against COVID-19, as well as the role of misinformation as a disincentive – especially when published by health professionals – and citizen acceptance of measures in this regard. Data from different surveys revealed a high degree of hesitation rather than outright opposition to vaccines. The most frequent complaint related to the COVID-19 vaccination was the fear of side effects. Within the Spanish and European legislative…
Health/Medicine | Education/Labor | Infectious Diseases | Decision Psychology | Preferences/Values | Social Determinants | Policy/Regulation | Culture/Society | Government/Law | Science/Technology | Global -
ArticlePublication 2020New Fronts in the War on Misinformation
The countless false claims that have spread alongside the novel coronavirus – inaccurate advice about …
The countless false claims that have spread alongside the novel coronavirus – inaccurate advice about how to prevent the virus, for example, and conspiracy theories about its origins – are just the latest manifestation of an ongoing problem: the online proliferation of misinformation about science and health. The National Academies hosted and helped organize three events focused on countering misinformation: The MisinfoCon conference, a Wikipedia Edit-a-thon, and a meeting to explore ways to expand successful…
Health/Medicine | Education/Labor | Infectious Diseases | Decision Psychology | Preferences/Values | Social Determinants | Policy/Regulation | Culture/Society | Government/Law | Science/Technology | North America -
BriefPublication 2019Brief: Safe Routes to School (SRTS) in Houston, Texas
This brief summarizes findings from the CHOICES Learning Collaborative Partnership simulation model of implementing Safe …
This brief summarizes findings from the CHOICES Learning Collaborative Partnership simulation model of implementing Safe Routes to School (SRTS) initiatives in elementary and middle schools in the Houston Independent School District. SRTS aims to help children safely walk and bicycle to school through infrastructure improvements, education, and promotional activities. The analysis compared the costs and outcomes over a 10-year time horizon (2017-2027) of implementing SRTS in Houston with the costs and outcomes associated with not…
Health/Medicine | Education/Labor | Chronic Disease/Risk | Cost-Effectiveness Analysis | Child/Nutrition | Policy/Regulation | Economics/Finance | North America -
BriefPublication 2020Brief: Active Physical Education (PE) in Allegheny County, Pennsylvania
This brief summarizes findings from the CHOICES Learning Collaborative Partnership simulation model of implementing an …
This brief summarizes findings from the CHOICES Learning Collaborative Partnership simulation model of implementing an Active Physical Education (PE) program in school districts participating in the Live Well Allegheny initiative in Allegheny County, Pennsylvania. Live Well Allegheny Schools will commit that 50% of PE class time be dedicated to moderate-to-vigorous physical activity. This analysis compared the costs and outcomes of the implementation of the Active PE program in designated school districts over a 10-year time horizon with the costs…
Health/Medicine | Education/Labor | Chronic Disease/Risk | Cost-Effectiveness Analysis | Child/Nutrition | Policy/Regulation | North America -
BookPublication 2019Non-Communicable Disease Prevention: Best Buys, Wasted Buys, Contestable Buys
Non-communicable diseases (NCDs) are the leading cause of death worldwide, and the majority of these …
Non-communicable diseases (NCDs) are the leading cause of death worldwide, and the majority of these deaths occur in low- and middle-income countries. This book provides practical guidelines and lessons learned through real-world case studies. It is intended to be informative to NCD program managers, policy officers and decision-makers in low- and middle-income countries, who need to comparatively assess interventions for the prevention and control of NCDs.The authors emphasize the importance of context in NCD control…
Health/Medicine | Chronic Disease/Risk | Infectious Diseases | Priority Setting/Ethics | Cost-Effectiveness Analysis | Technology Assessment | Health Systems | Policy/Regulation | Global -
ArticlePublication 2019Assessment of the Feasibility and Cost of Hepatitis C Elimination in Pakistan
This study investigates the feasibility and cost of hepatitis C virus (HCV) elimination in Pakistan …
This study investigates the feasibility and cost of hepatitis C virus (HCV) elimination in Pakistan using a decision analytical model and microsimulation techniques from 2015 to 2030. Various scenarios, including the status quo and seven elimination strategies, were evaluated based on Pakistan-specific variables. Main outcomes included trends in HCV prevalence, mortality, disability-adjusted life-years, and total costs of HCV care. Results suggest that to achieve HCV elimination by 2030, significant scale-up of testing and treatment is…
Health/Medicine | Chronic Disease/Risk | Infectious Diseases | Decision Analysis | Asia & Pacific -
ReportPublication 2010Priorities for the National Vaccine Plan
The authors examine the complexities of the vaccine enterprise, a fundamental component of preventive medicine …
The authors examine the complexities of the vaccine enterprise, a fundamental component of preventive medicine and public health, from research and development of new vaccines to financing and reimbursement of immunization services. The current climate, socially, economically and politically, presents challenges and opportunities to the U.S. to strengthen the existing systems of developing, manufacturing, regulating, distributing, funding, and administering safe and effective vaccines for all people. The authors present recommendations for priority actions intended to…
Health/Medicine | Chronic Disease/Risk | Infectious Diseases | Evidence Synthesis | Technology Assessment | Health Systems | Policy/Regulation | Economics/Finance | Science/Technology | North America -
ArticlePublication 2018Should We Treat Acute Hepatitis C? A Decision and Cost-Effectiveness Analysis
This study examines the potential benefits of treating acute hepatitis C virus (HCV) infection compared …
This study examines the potential benefits of treating acute hepatitis C virus (HCV) infection compared to deferring treatment until the chronic phase, utilizing a microsimulation model. By projecting long-term outcomes such as quality-adjusted life years (QALYs) and costs, the analysis evaluates the cost-effectiveness of initiating therapy during the acute phase. Results indicate that treating acute HCV increases QALYs by 0.02 and costs by $483 per patient not at risk of transmitting HCV, yielding an incremental…
Health/Medicine | Chronic Disease/Risk | Infectious Diseases | Microsimulation | Decision Analysis | Cost-Effectiveness Analysis | North America