Resources Repository
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ArticlePublication 2023Simulation-Based Comparative Effectiveness Analysis of Policies to Improve Global Maternal Health Outcomes
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) …
The Sustainable Development Goals include a target to reduce the global maternal mortality ratio (MMR) to less than 70 maternal deaths per 100,000 live births by 2030, with no individual country exceeding 140. However, on current trends the goals are unlikely to be met. The authors used an empirically calibrated Global Maternal Health microsimulation model, which simulates individual women in 200 countries and territories to evaluate the impact of different interventions and strategies from 2022…
Microsimulation | Mathematical Models | Calibration/Validation | Health/Medicine | Global | Clinical Care | Health Outcomes | Maternal/Reproductive Health | Health Systems -
ArticlePublication 2017Likelihood Approach for Calibration of Stochastic Epidemic Models
Stochastic transmission dynamic models are especially useful for studying the early emergence of novel pathogens …
Stochastic transmission dynamic models are especially useful for studying the early emergence of novel pathogens given the importance of chance events when the number of infectious individuals is small. However, methods for parameter estimation and prediction for these types of stochastic models remain limited. This paper describes a calibration and prediction framework for stochastic compartmental transmission models of epidemics. The proposed method applies a linear noise approximation to describe the size of the fluctuations, and…
Dynamic Simulation | Calibration/Validation | Dynamic Transmission | Health/Medicine | Global | Infectious Diseases | Health Systems -
ArticlePublication 2011Dynamic Policies for Controlling Spread of Emerging Infections
This paper illustrates the design and implementation of a dynamic health policy for the control …
This paper illustrates the design and implementation of a dynamic health policy for the control of a novel strain of influenza, where two types of interventions are assumed to be available during the epidemic: (1) vaccines and antiviral drugs, and (2) transmission reducing measures, such as social distancing or mask use, that may be turned "on" or "off" repeatedly during the course of epidemic. A modeling approach is described for developing dynamic health policies that allow…
Dynamic Simulation | Mathematical Models | Dynamic Transmission | Health/Medicine | Global | Infectious Diseases | Health Systems | Policy/Regulation | Science/Technology -
ArticlePublication 2023Simulation-Based Estimates and Projections of Global, Regional and Country-Level Maternal Mortality by Cause, 1990-2050
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given …
While progress has been made globally to reduce maternal deaths, measurement remains a challenge given the many causes and frequent underreporting of maternal deaths. The authors developed a structural microsimulation model of Global Maternal Health (GMatH) for 200 countries and territories using demographic, epidemiologic, clinical and health system data synthesized from the medical literature, Civil Registration Vital Statistics systems and Demographic and Health Survey data. The model was calibrated to empirical data from 1990 to…
Microsimulation | Calibration/Validation | Health/Medicine | Global | Clinical Care | Health Outcomes | Evidence Synthesis | Maternal/Reproductive Health | Health Systems -
ArticlePublication 2010Alternative Strategies to Reduce Maternal Mortality in India: A Cost-Effectiveness Analysis
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy …
This article, published in PLoS Medicine, conducted a cost-effectiveness analysis of strategies to improve pregnancy and childbirth safety in India. Country- and region-specific data were synthesized using a computer-based model that simulates the natural history of pregnancy and pregnancy-associated complications in individual women, and considers delivery location, attendant, and facility level. Model validation compared projected maternal indicators with empiric data. Strategies consisted of improving coverage of effective interventions that could be provided individually or packaged…
Microsimulation | Mathematical Models | Health/Medicine | Global | Evidence Synthesis | Cost-Effectiveness Analysis | Maternal/Reproductive Health | Economics/Finance | Asia & Pacific -
ArticlePublication 2021Misinformation and Public Opinion of Science and Health
This article summarizes the literature on misinformation, beginning with an overview of the most common …
This article summarizes the literature on misinformation, beginning with an overview of the most common definitions of misinformation (and related terms) in the communication literature and then a review of academic studies in the areas of science and health. The author acknowledges four overarching questions that have emerged prominently in recent years: (1) What does “misinformation” (and the terms that are oftentimes treated synonymously) mean? (2) How big of a problem is it in areas…
Decision Psychology | Energy/Engineering | Education/Labor | Global | Preferences/Values | Social Determinants | Climate/Environment | Culture/Society | Science/Technology | North America -
ArticlePublication 2019Misinformation Has Created a New World Disorder
This article, in brief, discusses (1) that many types of information disorder exist online, from …
This article, in brief, discusses (1) that many types of information disorder exist online, from fabricated videos to impersonated accounts to memes designed to manipulate genuine content, (2) automation and microtargeting tactics have made it easier for agents of disinformation to weaponize regular users of the social web to spread harmful messages, and (3) much research is needed to understand the effects of disinformation and build safeguards against it. This description was adapted from the…
Decision Psychology | Energy/Engineering | Health/Medicine | Global | Preferences/Values | Climate/Environment | Culture/Society | Government/Law | Science/Technology | North America -
ArticlePublication 2021COVID-19, Fake News, and Vaccines: Should Regulation Be Implemented?
This article analyzes issues concerning the establishment of compulsory vaccination against COVID-19, as well as …
This article analyzes issues concerning the establishment of compulsory vaccination against COVID-19, as well as the role of misinformation as a disincentive – especially when published by health professionals – and citizen acceptance of measures in this regard. Data from different surveys revealed a high degree of hesitation rather than outright opposition to vaccines. The most frequent complaint related to the COVID-19 vaccination was the fear of side effects. Within the Spanish and European legislative…
Decision Psychology | Health/Medicine | Education/Labor | Global | Preferences/Values | Infectious Diseases | Social Determinants | Policy/Regulation | Culture/Society | Government/Law | Science/Technology -
ArticlePublication 2019Cost-Effectiveness of Latent TB Screening before Immigration to Low-Incidence Countries
Despite prospective migrants to countries where the incidence of TB is low receiving TB screening …
Despite prospective migrants to countries where the incidence of TB is low receiving TB screening for active infections, screening for latent TB infection before immigration is rare. The authors used discrete event simulation to evaluate the cost-effectiveness preimmigration latent TB infection screening for migrants to low-incidence countries. They calculated cost per quality-adjusted life-year gained for migrants from countries with different TB incidences. Their analysis when combined with research on sustainability, acceptability, and program implementation can…
Dynamic Simulation | Mathematical Models | Health/Medicine | Global | Cost-Effectiveness Analysis | Infectious Diseases | Government/Law