Role and Contribution of Treatment and Imaging Modalities in Global Cervical Cancer Management
2020
Using a microsimulation model of global cancer survival, this analysis estimates the impact of scaling up treatment and imaging modalities on cervical cancer survival in 200 countries/territories. The paper evaluates the potential survival effect of scaling up treatment (chemotherapy, surgery, radiotherapy, and targeted therapy), and imaging modalities (ultrasound, x-ray, CT, MRI, PET, and single photon emission CT [SPECT]) to the mean level of high-income countries, both individually and in combination. The model estimates that global cervical cancer 5-year net survival is currently 42.1% (95% UI 33.8-48.5), with small gains from scaling-up any single treatment or imaging modality individually. However, scaling up all treatment modalities could improve global 5-year net survival to 52.4% (95% UI 44.6-62.0), and concurrently improving quality of care could raise survival to 57·5% (51·2-63·5), while a comprehensive scale-up including imaging could improve 5-year net survival for cervical cancer to 62.5% (57.7-67.8). Comprehensive scale-up of treatment, imaging, and quality of care could thus substantially improve global cervical cancer 5-year net survival, with quality of care and imaging improvements each contributing about 25% of the total potential gains.
Role and Contribution of Treatment and Imaging Modalities in Global Cervical Cancer Management
Source:
Ward ZJ, Grover S, Scott AM et al. The Role and Contribution of Treatment and Imaging Modalities in Global Cervical Cancer Management: Survival Estimates from a Simulation-Based Analysis. The Lancet Oncology 2020; 21 (8): 1089-1098. https://doi.org/10.1016/s1470-2045(20)30316-8
Not open access.