Translating Population Evidence to Individual Patients
2020
In this paper, the authors describe the differences in population level outcomes compared to individual patients and discuss ways that these are differences. The authors cover topics including the difference between relative and absolute risk and benefit. They use an example of the decision to start anticoagulation in new-onset atrial fibrillation to discuss translating population level evidence to treatment of an individual. These options include generalizability, subgroup analysis, prediction rules, following response to therapy, and even potentially using individual/precision medicine.
Translating Population Evidence to Individual Patients
Source:
Armstrong KA, Metlay JP. Clinical Decision Making: Translating Population Evidence to Individual Patients. Annals of Internal Medicine 2020; 172 (9): 610-616. https://doi.org/10.7326/M19-3496
Not open access.