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ArticlePublication 2008Community and Patient Values for Preventing Herpes Zoster
In this 2008 article, the authors report on a survey to assess the value individuals …
In this 2008 article, the authors report on a survey to assess the value individuals place on preventing herpes zoster. The Zoster Vaccine Live (ZVL) was recommended for routine use in adults aged ≥60 years. Members of the population (“community members”, n= 527), patients with shingles (n= 382) or post-herpetic neuralgia (PHN, n = 137) completed an internet or telephone survey to assess the value they place on preventing herpes zoster. The authors used standard…
Health Outcomes | Preferences/Values | Culture/Society | Health/Medicine | North America -
ArticlePublication 2007Measuring Health Preferences for Use in Analyses of Interventions in Children
Valuing the health of children for cost-utility or cost-benefit analysis is more challenging than valuing …
Valuing the health of children for cost-utility or cost-benefit analysis is more challenging than valuing adult health. Young children cannot conceptualize value, they are not responsible for their own decision making, and proxies may not fully understand the child perspective. Moreover illness in children may affect parent/caregiver health and quality of life, further complicating the measurement of value associated with a change in a child’s health status.This paper reviews the most common approaches (QALYs and willingness-to-pay)…
Health Outcomes | Preferences/Values | Infectious Diseases | Child/Nutrition | North America | Europe -
GuidelinesPublication 2016Decision Models in Clinical Preventive Services Recommendations
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on …
The U.S. Preventive Services Task Force (USPSTF) develops evidence-based recommendations about preventive care based on comprehensive systematic reviews of the best available evidence. Decision models provide a complementary, quantitative approach to support the USPSTF as it deliberates about the evidence and develops recommendations for clinical and policy use. This article describes the rationale for using modeling, an approach to selecting topics for modeling, and how modeling may inform recommendations about clinical preventive services.
Evidence Synthesis | Health Outcomes | Mathematical Models | Decision Analysis | Health Systems | Policy/Regulation | Health/Medicine | North America -
ArticlePublication 2017Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Subunit Vaccine in Adults Previously Vaccinated
This article reports on a clinical trial of the new herpes zoster vaccine (HZ subunit …
This article reports on a clinical trial of the new herpes zoster vaccine (HZ subunit vaccine, HZ/su) among individuals previously vaccinated with the live-attenuated zoster vaccine Zostavax (ZVL; immunity known to wane within 3-7 years) and previously unvaccinated individuals (multicenter study (NCT02581410)). Among a sample of 430 adults age 65+ years, HZ/su induces a strong immune response irrespective of prior vaccination with ZVL. They conclude that HZ/su may be an attractive option to re-vaccinate…
Health Outcomes | Infectious Diseases | Health/Medicine | Science/Technology | North America -
ArticlePublication 2017Immunogenicity and Safety of an Adjuvanted Herpes Zoster Subunit Vaccine Co-Administered with Influenza Vaccine in Adults
This article reports on a clinical trial (NCT01954251) of herpes zoster subunit vaccine (HZ/su) co-administered …
This article reports on a clinical trial (NCT01954251) of herpes zoster subunit vaccine (HZ/su) co-administered with a quadrivalent seasonal inactivated influenza vaccine (IIV4) in adults age 50 years and older. Outcome measures were vaccine response rate and antibody response in the intervention compared to control groups. There were 413 subjects in the intervention group and 415 in the control. Antibody response was within statistical limits for similarity between the two groups; no safety concerns were…
Health Outcomes | Infectious Diseases | Health/Medicine | Science/Technology | North America -
ArticlePublication 2017Analysis of Real-World Health Care Costs among Patients Aged 50 Years or Older with Herpes Zoster
This article reports on the direct costs associated with herpes zoster (HZ) and postherpetic neuralgia …
This article reports on the direct costs associated with herpes zoster (HZ) and postherpetic neuralgia (PHN) in the U.S. The authors use a retrospective managed care insurance claims database of 142,519 patients with herpes zoster (9,470 patients [6.6%] had postherpetic neuralgia) and 357,907 matched controls. They found that resource utilization was greater among patients with herpes zoster: after adjusting for demographic and clinical characteristics, annual incremental health care costs for herpes zoster patients vs. controls…
Evidence Synthesis | Costing Methods | Infectious Diseases | Economics/Finance | Health/Medicine | North America -
ReviewPublication 2015Humanistic, Economic and Societal Burden of Herpes Zoster in Europe
This review provides documentation and critical appraisal of published data concerning the humanistic, economic and …
This review provides documentation and critical appraisal of published data concerning the humanistic, economic and societal burden of herpes zoster (HZ) in Europe. From a review of 1619 abstracts, 53 eligible articles, were identified which reported data concerning healthcare resource use (n = 38), direct costs (n = 20), indirect costs (n = 16), total costs (n = 10) and impact on health-related quality of life (HRQoL) (n = 21).The findings indicate that postherpetic neuralgia…
Health Outcomes | Costing Methods | Preferences/Values | Cost-Effectiveness Analysis | Infectious Diseases | Europe
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