Immunogenicity and Safety of an Adjuvanted Herpes Zoster Subunit Vaccine Co-Administered with Influenza Vaccine in Adults
2017
This article reports on a clinical trial (NCT01954251) of herpes zoster subunit vaccine (HZ/su) co-administered with a quadrivalent seasonal inactivated influenza vaccine (IIV4) in adults age 50 years and older. Outcome measures were vaccine response rate and antibody response in the intervention compared to control groups.
There were 413 subjects in the intervention group and 415 in the control.
Antibody response was within statistical limits for similarity between the two groups; no safety concerns were raised.
The authors conclude that there was no interference in the immune response to either vaccine when they are co-administered.
Source:
Schwarz TF, Aggarwal N, Moeckesch B et al. Immunogenicity and Safety of an Adjuvanted Herpes Zoster Subunit Vaccine Co-Administered with Seasonal Influenza Vaccine in Adults Aged 50 Years and Older. The Journal of Infectious Diseases 2017; 216 (11): 1352-1361. https://doi.org/10.1093/infdis/jix481