-
ArticlePublication 2008Cost-Effectiveness of Atypical Antipsychotics in the U.K.
This article, published in Value in Health, describes an adapted version of an earlier published …
This article, published in Value in Health, describes an adapted version of an earlier published discrete event simulation (DES) model that aims to estimate the cost-effectiveness of atypical relative to conventional antipsychotics for the treatment of schizophrenia in the UK. Over a 5-year period, the disease and treatment history of the patients is monitored in terms of symptoms (using the Positive and Negative Symptom Score [PANSS]), psychiatrist visits, pharmacological treatment and treatment location, number and…
Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ReviewPublication 2017Model-Based Economic Evaluation of Treatments for Depression: A Systematic Review
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies …
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies evaluating the cost-effectiveness of treatments for depression and examine the appropriateness of different modelling technique for simulating the natural course of depression. The review yielded 41 model-based studies, of which 21 used decision trees (DTs), 15 used cohort-based state-transition Markov models (CMMs), two used individual-based state-transition models (ISMs), and three used discrete-event simulation (DES) models. Just over half of the…
Microsimulation | Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ReviewPublication 2012A Critical Review of Model-Based Economic Studies of Depression
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The …
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The strengths and limitations of different modeling techniques and the factors influencing the choice for a specific modeling technique is discussed. The authors also address the appropriateness of model structure and data sources used to populate the models. This review identifies fourteen model-based studies including 8 studies that developed decision trees, 5 studies used Markov models, and one study a Markov…
Microsimulation | Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2012Cost-Effectiveness of Antidepressants and CBT for Major Depression in Thailand
This article, published in Value in Health, describes the adaptation of an earlier published discrete …
This article, published in Value in Health, describes the adaptation of an earlier published discrete event simulation model to compare the cost-effectiveness of fluoxetine and cognitive-behavioral therapy (CBT) to a “do-nothing” scenario for major depression in Thailand. Fluoxetine and CBT are analyzed for episodic treatment and for 5-year maintenance treatment. Model inputs are derived from Thai data on disease parameters, while costs and impact parameters are obtained from a systematic review and meta-analysis of the…
Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Asia & Pacific -
ArticlePublication 2012Cost Effectiveness of Quetiapine in Bipolar Depression
This article, published in Pharmacoeconomics, presents a discrete event simulation model to investigate the cost-effectiveness …
This article, published in Pharmacoeconomics, presents a discrete event simulation model to investigate the cost-effectiveness of quetiapine compared with olanzapine in patients with acute bipolar depression and in maintenance treatment after an acute depressive episode in the UK. The following events are possible in the model: stable patient (remission), depressive episode, manic episode and mortality. A patient will move to a next event based on time-to-event functions. The analysis is conducted from the societal perspective…
Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2017Costs and Benefits of Insuring Psychological Services for Depression in Canada
This article, published in Psychiatric Services, describes the development of a discrete event simulation model …
This article, published in Psychiatric Services, describes the development of a discrete event simulation model to investigate the costs and effects of increasing access to publicly-funded psychotherapy for depression compared to the status quo in a public health care system in Canada. The analyses from both the societal and health system perspective are conducted over a 40-year time horizon. Data on the probability of events, costs (direct and indirect), and utility estimates are obtained from…
Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ArticlePublication 2006Can Discrete Event Simulation be of Use in Modeling Major Depression?
This article, published in Cost Effectiveness and Resource Allocation, reviews the published literature on Markov …
This article, published in Cost Effectiveness and Resource Allocation, reviews the published literature on Markov models in depression and identified potential limitations in using this particular modelling approach in this disease area. Additionally, the authors develop a “Discrete Event Simulation” (DES) model to investigate the benefits and drawbacks of this simulation method compared with Markov modelling techniques. The findings of this study indicate that the most important limitation of using Markov models in depression is…
Microsimulation | State-Transition | Decision Analysis | Mental Health | Health/Medicine -
ArticlePublication 2012Modeling the Risks and Benefits of Depression Treatment for Children and Young Adults
This article, published in Value in Health, presents a discrete event simulation model to quantify …
This article, published in Value in Health, presents a discrete event simulation model to quantify the trade-offs with respect to clinical benefits and the risk of fatal and non-fatal suicidal behavior of alternative treatment strategies for a U.S. pediatric population with major depressive disorder. The authors evaluate treatment strategies including: selective serotonin reuptake inhibitors (SSRIs), cognitive behavioral therapy (CBT), and a combination of both. The results show that the use of SSRIs is associated with…
Microsimulation | Health Outcomes | Technology Assessment | Mental Health | Health/Medicine | North America -
ReviewPublication 2014Systematic Review of Model-Based Economic Evaluations of Drugs in Bipolar Disorder
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature …
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature on model-based economic evaluations of pharmacotherapeutics in patients with bipolar disorders. This review identifies 14 studies. Of these 14 studies, nine use Markov, three use discrete-event simulation (DES) and two use decision-tree models. Most of the studies (n = 11) do not include the rationale for the choice of modelling technique undertaken. Half of the studies do not include the…
Microsimulation | Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2008Modelling Approaches: The Case of Schizophrenia
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using …
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using both cohort and microsimulation approaches) and discrete event simulation models in the case of schizophrenia. Schizophrenia is a complex disease with considerable variation in the course of disease between individual patients. The three modelling techniques are compared in terms of their ability to deal with this patient heterogeneity, building time, data requirements, medico-scientific experience, simulation time, clinical representation, the timing…
Microsimulation | Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine
10 Shown
Teaching Resources
Collections
Format
Learner Level
Teaching Topic