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ArticlePublication 2012Estimated Benefits of Atypical Antipsychotics in Schizophrenia: A Decision Model
This article, published in Annals of General Psychiatry, describes the development of a decision tree model …
This article, published in Annals of General Psychiatry, describes the development of a decision tree model with Markov processes to quantify the resources used and the corresponding burden of disease due to a projected reduction in relapse frequency resulting from further improvements in medication compliance in patients with schizophrenia. The analyses are conducted from the third party payer perspective and outcomes are modeled over a one-year and five-year time horizon. Three delivery technologies are compared: a…
Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ArticlePublication 2016Cost-Effectiveness of Off-Label Antipsychotics in Children and Adolescents
This article, published in Attention Deficit and Hyperactivity Disorders, presents a decision tree to evaluate …
This article, published in Attention Deficit and Hyperactivity Disorders, presents a decision tree to evaluate the cost-effectiveness of atypical antipsychotics (AAPs) to other non-stimulant ADHD medications in treating children and adolescents with ADHD who failed initial stimulant treatment. The strategies compared in the analysis are: (1) AAPs, (2) a selective norepinephrine reuptake inhibitor (atomoxetine), and (3) selective α2-adrenergic agonists (clonidine and guanfacine). Data on the input parameters of the model are derived from the literature.…
Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ReviewPublication 2017Model-Based Economic Evaluation of Treatments for Depression: A Systematic Review
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies …
This article, published in Pharmacoeconomics, systematically reviews the literature in order to identify model-based studies evaluating the cost-effectiveness of treatments for depression and examine the appropriateness of different modelling technique for simulating the natural course of depression. The review yielded 41 model-based studies, of which 21 used decision trees (DTs), 15 used cohort-based state-transition Markov models (CMMs), two used individual-based state-transition models (ISMs), and three used discrete-event simulation (DES) models. Just over half of the…
Mathematical Models | State-Transition | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ReviewPublication 2012A Critical Review of Model-Based Economic Studies of Depression
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The …
This article, published in PharmacoEconomics, reviews the literature on model-based cost-utility studies of depression. The strengths and limitations of different modeling techniques and the factors influencing the choice for a specific modeling technique is discussed. The authors also address the appropriateness of model structure and data sources used to populate the models. This review identifies fourteen model-based studies including 8 studies that developed decision trees, 5 studies used Markov models, and one study a Markov…
Mathematical Models | State-Transition | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2006Treatment for Moderate and Severe Depression: Decision Analysis for a Clinical Guideline
This article, published in the British Journal of Psychiatry, presents a decision tree model that …
This article, published in the British Journal of Psychiatry, presents a decision tree model that compares the cost-effectiveness of different treatment options for patients with moderate to severe depression in secondary care in the UK (i.e., antidepressants, psychological therapy and a combination of the two). Clinical, utility, and cost data were obtained from the published literature. Over the 15-month analysis period, results indicate that combination therapy result in higher costs and an expected 0.16 increase…
Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2014Cost-Effectiveness of Asenapine in the Treatment of Bipolar Disorder in Canada
This article, published in BMC Psychiatry, presents a decision tree combined with a Markov model …
This article, published in BMC Psychiatry, presents a decision tree combined with a Markov model that estimates the cost-effectiveness of asenapine compared with olanzapine in the treatment of bipolar disorder in Canada. The decision tree part of the model takes into account the occurrence of extrapyramidal symptoms, the probability of switching to a different antipsychotic, and the probability of gaining weight. The Markov model part takes into account the long-term metabolic complications including diabetes, hypertension,…
Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | North America -
ReviewPublication 2014Systematic Review of Model-Based Economic Evaluations of Drugs in Bipolar Disorder
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature …
This article, published in Applied Economics and Health Policy, systematically and critically reviews the literature on model-based economic evaluations of pharmacotherapeutics in patients with bipolar disorders. This review identifies 14 studies. Of these 14 studies, nine use Markov, three use discrete-event simulation (DES) and two use decision-tree models. Most of the studies (n = 11) do not include the rationale for the choice of modelling technique undertaken. Half of the studies do not include the…
Mathematical Models | State-Transition | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2008Modelling Approaches: The Case of Schizophrenia
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using …
This article, published in Pharmacoeconomics, evaluates three modelling techniques including decision trees, Markov models (using both cohort and microsimulation approaches) and discrete event simulation models in the case of schizophrenia. Schizophrenia is a complex disease with considerable variation in the course of disease between individual patients. The three modelling techniques are compared in terms of their ability to deal with this patient heterogeneity, building time, data requirements, medico-scientific experience, simulation time, clinical representation, the timing…
Mathematical Models | State-Transition | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2012Effectiveness and Cost-Effectiveness of Antidepressants in Primary Care
This article, published in PLoS One, presents a decision tree model to compare the effectiveness …
This article, published in PLoS One, presents a decision tree model to compare the effectiveness and cost-effectiveness of pharmacological first line treatment in primary care for patients with moderate to severe depression. The authors compare 10 antidepressants (citalopram, duloxetine escitalopram, fluoxetine, fluvoxamine mirtazapine, paroxetine, reboxetine, sertraline and venlafaxine) over a one-year time horizon. A meta-analysis was conducted to obtains the remission rates from randomized controlled trials and cost and quality-adjusted life years (QALYs) were obtained…
Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe -
ArticlePublication 2015Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder
This article, published in PLoS One, presents a decision tree model followed by a two-state …
This article, published in PLoS One, presents a decision tree model followed by a two-state Markov model that evaluates 28 psychological and pharmacological interventions for social anxiety disorder. The pharmacological interventions include seven selective serotonin/serotonin-noradrenergic reuptake inhibitors, two monoamine oxidase inhibitors (including phenelzine), one anticonvulsant, one noradrenergic and specific serotonergic antidepressant. The psychological interventions include self-help without therapist support (book- and computer-based), self-help with therapist support (book- and computer-based), exposure in vivo, mindfulness training, two…
Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine | Europe
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