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ArticlePublication 2008Cost-Effectiveness of Atypical Antipsychotics in the U.K.
This article, published in Value in Health, describes an adapted version of an earlier published …
This article, published in Value in Health, describes an adapted version of an earlier published discrete event simulation (DES) model that aims to estimate the cost-effectiveness of atypical relative to conventional antipsychotics for the treatment of schizophrenia in the UK. Over a 5-year period, the disease and treatment history of the patients is monitored in terms of symptoms (using the Positive and Negative Symptom Score [PANSS]), psychiatrist visits, pharmacological treatment and treatment location, number and…
Europe | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2006Model to Assess the Cost-Effectiveness of New Treatments for Depression
This article, published in the International Journal of Technology Assessment in Health Care, describes a …
This article, published in the International Journal of Technology Assessment in Health Care, describes a Markov model to compare the cost-effectiveness of a hypothetical new treatment for depression with standard care. Data on costs, quality of life and transition probabilities are derived from the observational Health Economic Aspects of Depression in Sweden (HEADIS) study. Data on long-term consequences of depression and mortality risks are obtained from the published literature. The analyses are conducted from the…
Europe | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2012Cost Effectiveness of Quetiapine in Bipolar Depression
This article, published in Pharmacoeconomics, presents a discrete event simulation model to investigate the cost-effectiveness …
This article, published in Pharmacoeconomics, presents a discrete event simulation model to investigate the cost-effectiveness of quetiapine compared with olanzapine in patients with acute bipolar depression and in maintenance treatment after an acute depressive episode in the UK. The following events are possible in the model: stable patient (remission), depressive episode, manic episode and mortality. A patient will move to a next event based on time-to-event functions. The analysis is conducted from the societal perspective…
Europe | Microsimulation | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2006Treatment for Moderate and Severe Depression: Decision Analysis for a Clinical Guideline
This article, published in the British Journal of Psychiatry, presents a decision tree model that …
This article, published in the British Journal of Psychiatry, presents a decision tree model that compares the cost-effectiveness of different treatment options for patients with moderate to severe depression in secondary care in the UK (i.e., antidepressants, psychological therapy and a combination of the two). Clinical, utility, and cost data were obtained from the published literature. Over the 15-month analysis period, results indicate that combination therapy result in higher costs and an expected 0.16 increase…
Europe | Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2016Cost-Effectiveness of Collaborative Care for Depression and Comorbid Diabetes or CVD
This article, published in BMJ Open, presents an economic model that combines a decision tree …
This article, published in BMJ Open, presents an economic model that combines a decision tree and a Markov cohort model to investigate the long-term cost-effectiveness of collaborative care versus usual care for individuals with depression and comorbid diabetes and/or cardiovascular disease. Data from the COINCIDE trial informs the model input parameters. The COINCIDE trial is a randomized controlled trial of collaborative care versus usual care that enrolled 387 participants from 36 primary care general practices…
Europe | State-Transition | Cost-Effectiveness Analysis | Chronic Disease/Risk | Mental Health | Health/Medicine -
ArticlePublication 2011Cost-Effectiveness of Aripiprazole versus Olanzapine in Schizophrenia and Bipolar Disorder
This article, published in Acta Psychiatrica Scandinavica, describes a Markov model that estimates the cost-effectiveness …
This article, published in Acta Psychiatrica Scandinavica, describes a Markov model that estimates the cost-effectiveness of aripiprazole versus olanzapine in the treatment of patients with schizophrenia or bipolar disorder in Sweden with a focus on the metabolic impact of the treatments. The health-state transition model consists of five health states: no metabolic syndrome, metabolic syndrome, diabetes, coronary heart disease, and death. The analyses are conducted over a lifetime, with a cycle length of one year.…
Europe | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2012Effectiveness and Cost-Effectiveness of Antidepressants in Primary Care
This article, published in PLoS One, presents a decision tree model to compare the effectiveness …
This article, published in PLoS One, presents a decision tree model to compare the effectiveness and cost-effectiveness of pharmacological first line treatment in primary care for patients with moderate to severe depression. The authors compare 10 antidepressants (citalopram, duloxetine escitalopram, fluoxetine, fluvoxamine mirtazapine, paroxetine, reboxetine, sertraline and venlafaxine) over a one-year time horizon. A meta-analysis was conducted to obtains the remission rates from randomized controlled trials and cost and quality-adjusted life years (QALYs) were obtained…
Europe | Mathematical Models | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2015Cost Effectiveness of Psychological and Pharmacological Interventions for Social Anxiety Disorder
This article, published in PLoS One, presents a decision tree model followed by a two-state …
This article, published in PLoS One, presents a decision tree model followed by a two-state Markov model that evaluates 28 psychological and pharmacological interventions for social anxiety disorder. The pharmacological interventions include seven selective serotonin/serotonin-noradrenergic reuptake inhibitors, two monoamine oxidase inhibitors (including phenelzine), one anticonvulsant, one noradrenergic and specific serotonergic antidepressant. The psychological interventions include self-help without therapist support (book- and computer-based), self-help with therapist support (book- and computer-based), exposure in vivo, mindfulness training, two…
Europe | Mathematical Models | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2010Cost-Effectiveness of Psychotherapy for Cluster B Personality Disorders
This article, published in the British Journal of Psychiatry, presents a probabilistic Markov cohort model …
This article, published in the British Journal of Psychiatry, presents a probabilistic Markov cohort model that compares the cost-effectiveness of three treatment strategies (outpatient, day-hospital and inpatient psychotherapy) for patients with cluster B personality disorders. Patient-level data is used to populate the model and the analyses are conducted from the societal and payer perspectives. From the societal perspective, the findings show that the incremental cost-effectiveness ratio (ICER) of day hospital psychotherapy compared to outpatient psychotherapy…
Europe | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine -
ArticlePublication 2011Cost-Effectiveness of Psychotherapy for Cluster C Personality Disorders
This article, published in the Journal of Clinical Psychiatry, describes a probabilistic Markov cohort model …
This article, published in the Journal of Clinical Psychiatry, describes a probabilistic Markov cohort model that compares the cost-effectiveness of five treatment modalities (long-term outpatient psychotherapy, short-term and long-term day hospital psychotherapy, and short-term and long-term inpatient psychotherapy) for patients with cluster C personality disorders. The analyses are conducted from the societal and payer perspectives. Patient-level data comes from 466 patients with cluster C personality disorders who were admitted to 6 specialist centers of psychotherapy…
Europe | State-Transition | Cost-Effectiveness Analysis | Mental Health | Health/Medicine
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