Including Boys in an HPV Vaccination Program: A CEA in a Low-Resource Setting
2007
This paper looks at the cost-effectiveness of including boys vs girls alone in a pre-adolescent vaccination program against human papillomavirus (HPV) types 16 and 18 in Brazil. Using demographic, epidemiological, and cancer data from Brazil, the authors developed a dynamic transmission model of HPV infection between males and females. Model-projected reductions in HPV incidence under different vaccination scenarios were applied to a stochastic model of cervical carcinogenesis to project lifetime costs and benefits.
They found that at 90% coverage, vaccinating girls alone reduced cancer risk by 63%; including boys at this coverage level provided only 4% further cancer reduction; at a cost per-vaccinated individual of USD 50, vaccinating girls alone was alone was < USD 200 per year of life saved (YLS), while including boys ranged from USD 810-18,650 per YLS depending on coverage. For all coverage levels, the authors concluded that increasing coverage in girls was more effective and less costly than including boys in the vaccination program.
Including Boys in an HPV Vaccination Program: A CEA in a Low-Resource Setting
Source:
Kim JJ, Andres-Beck B, Goldie SJ. The Value of Including Boys in an HPV Vaccination Programme: A Cost-Effectiveness Analysis in a Low-Resource Setting. British Journal of Cancer 2007; 97 (9): 1322-1328. https://doi.org/10.1038/sj.bjc.6604023