Single-Arm Trial Design Estimates Efficacy
2023
Studies to confirm the efficacy of a single HPV vaccine dose, of vaccine durability, and of vaccination modifications are needed, but randomized controlled trials are costly and face logistical and ethical challenges. In this study, the authors demonstrate proof-of-principle that a single-arm design yields valid estimates with similar precision to a randomized controlled trial.
Single-Arm Trial Design Estimates Efficacy
Source:
Befano B, Campos NG, Egemen D et al. Estimating Human Papillomavirus Vaccine Efficacy from a Single-Arm Trial: Proof-of-Principle in the Costa Rica Vaccine Trial. Journal of the National Cancer Institute 2023.
https://doi.org/10.1093/jnci/djad064