Systematic Review of Economic Evaluations of Vaccination Strategies Against Tuberculosis


Bacillus Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis, but its effectiveness is limited and varies by age, so a valid cost-effectiveness study is needed to assist decision-makers in the implementation of cost-effective strategies for BCG vaccination. Using the Quality of Health Economic Studies (QHES) instrument, the authors assessed the quality of published studies involving economic evaluations of BCG vaccination strategies in a variety of regions, target populations, and vaccine types.  Most of the studies showed a favorable economic profile of BCG vaccination. A novel vaccine - either a BCG replacement or booster vaccine that provides better protection, especially in adults - has the potential to enhance the cost-effectiveness of vaccinating against tuberculosis.



Machlaurin A, Pol SV, Setiawan D et al. Expert Rev Vaccines. 2019:1-15. doi: 10.1080/14760584.2019.1651650.

Not open access.