Cost-Effectiveness of Rotavirus Vaccination in Vietnam
2009
This article reports on a cost-effectiveness analysis of rotavirus vaccination, including varying degrees of severity, age-dependency of clinical manifestation, and additional features of the disease (e.g., the possibility of reinfection and varying degrees of partial immunity conferred by natural infection).
The authors developed a Markov model that reflects key features of rotavirus infection, using the most recent data available at the time of their analysis. They applied the model to the 2004 Vietnamese birth cohort and re-evaluated the cost-effectiveness (2004 US dollars per disability-adjusted life year [DALY]) of rotavirus vaccination (Rotarix) compared to no vaccination, from both societal and health care system perspectives. They conducted univariate and probabilistic sensitivity analyses.
Findings included that rotavirus vaccination would not completely protect young children against infection due to the partial nature of vaccine immunity, but would effectively reduce severe cases of rotavirus gastroenteritis (outpatient visits, hospitalizations, or deaths) by about 67% over the first 5 years of life. Under base-case assumptions (94% coverage and $5 per dose), the incremental cost per DALY averted from vaccination compared to no vaccination would be $540 from the societal perspective and $550 from the health care system perspective.
Cost-Effectiveness of Rotavirus Vaccination in Vietnam
Source:
Kim SY, Goldie SJ, Salomon JA. Cost-Effectiveness of Rotavirus Vaccination in Vietnam. BMC Public Health 2009; 9: 29. https://doi.org/10.1186/1471-2458-9-29