Modeling Cervical Cancer Prevention in Developed Countries
2008
Decision-analytic models are increasingly developed to simulate disease burden and interventions in different settings in order to evaluate the benefits and cost-effectiveness of primary and secondary interventions. This article is a review of mathematical models that have been used to evaluate HPV vaccination in the context of developed countries with existing screening programs.
Despite variations in model assumptions and uncertainty in existing data, pre-adolescent vaccination of females in the setting of current screening practices has been consistently shown to be attractive, provided there is complete lifelong vaccine protection and high vaccination coverage. There was far more uncertainty found in regard to catch-up vaccination programs, benefits of including boys, and outcomes other than cervical cancer with conflicting conclusions reported. This review serves to highlight points of consensus, areas of divergence and to provide insight into critical decisions related to cervical cancer prevention.
Modeling Cervical Cancer Prevention in Developed Countries
Source:
Kim JJ, Brisson M, Edmunds WJ, Goldie SJ. Modeling Cervical Cancer Prevention in Developed Countries. Vaccine 2008; 26 (Suppl 1): K76-K86. https://doi.org/10.1016/j.vaccine.2008.06.009
Not open access.