Empirically Calibrated Model of Hepatitis C Virus Infection in the United States
2002
This article presents an epidemiologic model of hepatitis C in the United States. The authors used empirical calibration of model parameters to gain insights into uncertainty in the natural history of hepatitis C and to improve future projections.
The authors identified model inputs by way of a systematic review. Model simulations were conducted and model predictions were compared with epidemiologic data on infection prevalence and mortality from liver cancer. Goodness-of-fit criteria were used to identify parameter values that were consistent with these data.
Results indicated that rates of progression to advanced liver disease may be lower than previously assumed. The authors also found a wide range of plausible assumptions about heterogeneity beyond what could be explained by age and sex that were all consistent with observed epidemiologic trends.
Empirically Calibrated Model of Hepatitis C Virus Infection in the United States
Source:
Salomon JA, Weinstein MC, Hammitt JK, Goldie SJ. Empirically Calibrated Model of Hepatitis C Virus Infection in the United States. American Journal of Epidemiology 2002; 156 (8): 761-773. https://www.ncbi.nlm.nih.gov/pubmed/12370165
Not open access.